Sloan-Kettering Institute for Cancer Research

Cornell University

Jón T Njardarson

Samuel J Danishefsky

Christoph Gaul

David A Scheinberg

Michael R McDevitt

Xin-Yun Huang

Rena May

Mihirbaran Mandal

Malcolm A S Moore

Christophe Antczak

Mark Reid Philips

Debjit Chattopadhyay

David C Dorn

Kaida Wu

In one aspect, the present invention provides a method for treating colon and/or ovarian cancer in a subject comprising administering to a subject in need thereof a compound of general formula (I): wherein R1-R6, R, -R, Q, Y1, Y2 and n are as defined herein, wherein the compound is present in an amount effective to inhibit colon and/or ovarian tumor metastasis. 

Migrastatin analogs in the treatment of cancer

The present invention provides soluble single wall nanotube constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble single wall carbon nanotube via a DNA or other oligomer platform attached to the single wall carbon nanotube. These soluble single wall carbon nanotube constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble single wall carbon nanotube constructs.

Single wall nanotube constructs and uses therefor

In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I),  In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.

Migrastatin analog compositions and uses thereof

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Ithaca, NY, United States of America

Jón T Njardarson