Tohoku University

Jyunken Aoki

Hiroaki Shimokawa

Kimio Satoh

Ryo Kurosawa

Takayuki Doi

Kuniyuki Kano

Haruhisa Kikuchi

Yoshiteru Oshima

Hidetoshi Tokuyama

Hirofumi Ueda

The present invention provides a preventive or therapeutic agent for pulmonary hypertension, including a compound represented by the following formula (I) or a salt thereof: where: &#x2014;A&#x2014; represents &#x2014;NH&#x2014;, &#x2014;S&#x2014;, or &#x2014;O&#x2014;; Rand Rare identical to or different from each other, and each represent a hydrogen atom or an alkyl group; Rrepresents a hydrogen atom, a halogen atom, or an alkyl group; Rrepresents a hydrogen atom or an alkyl group; Rrepresents a hydrogen atom or an alkyl group; Rand Rare identical to or different each other, and each represent a hydrogen atom, a halogen atom, or an alkyl group; and Rand Rmay form an unsaturated hydrocarbon six-membered ring together with a carbon atom to which Ris bonded and a carbon atom to which Ris bonded.

Prophylactic or therapeutic agent for pulmonary hypertension comprising unsaturated 5-membered heterocycle-containing compound

A problem to be solved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension containing emetine or a salt thereof.

Pulmonary hypertension preventative or therapeutic agent containing crude drug

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Miyagi, Japan

Jyunken Aoki