Academia Sinica

Personal Genomics, Inc.

Jyun-Yuan Huang

Ching-Wei Tsai

Chao-Chi Pan

Li-Chi Chang

Chiaho Shih

Ching-Long Hwong

Shiuan-Woei Lin Wu

Ting-Yueh Tsai

A composition comprising a recombinant DNA polymerase and 3'-esterified nucleotide analogues is provided. The recombinant DNA polymerase includes an amino acid sequence that is at least 90% homology with 9&#xb0; N DNA polymerase (SEQ ID NO: 1), and the recombinant DNA polymerase includes at least two mutations at the positions corresponding to amino acid residues 141 and 143 of the 9&#xb0; N DNA polymerase. A recombinant DNA polymerase is further provided. The recombinant DNA polymerase includes an amino acid sequence that is at least 90% homology with 9&#xb0; N-III DNA polymerase (SEQ ID NO: 3), and the recombinant DNA polymerase includes one or two mutations at the positions corresponding to amino acid residue 480 and 486 of the 9&#xb0; N-III DNA polymerase. A method of performing a polymerization reaction is also provided.

Recombinant DNA polymerase for improved incorporation of nucleotide analogues

Methods and pharmaceutical compositions for regulating hepatitis virus replication, involving a miR-130a RNA, a miR-130b RNA, a miR-204 RNA, a miR-1236 RNA, or a combination thereof.

Treating hepatitis virus infection by modulating microRNAs miR-130a, miR-130b, miR-204, or miR-1236

Growing community of inventors

Kaohsiung, Taiwan

Jyun-Yuan Huang