Bayer Oy

Orion Diagnostica

Jyrki Pihlaja

Manja Ahola

Heikki Lyytikäinen

Harri Jukarainen

Ulrike Fuhrmann

Bernhard Lindenthal

Ina Gröticke

Satu Kleemola

Tuula Valo

Sakari Kulmala

Jouko Kankare

Timo Ala-Kleme

Svante Holmberg

Tero Parkatti

Bernd Duesterberg

Antti Keinänen

Kari Loikas

Timo Sutela

Mauri Nauma

Raili Valli

Pentti Juhala

Rainer Kappi

Keijo Haapakka

Henriikka Korolainen

Piia Hara

Risto Hakala

Jenny Hollaender

Anu-Liisa Honka

The present invention relates to a method for modifying release of a therapeutically active agent from an elastomeric matrix, comprising providing a core comprising an elastomeric matrix and a therapeutically active agent; dipping the core to a coating solution of an elastomer, wherein the elastomer comprises 20-35 wt-% of a filler, calculated from the total amount of filler and elastomer; curing the dipped core to provide a coated core. In this method the dipping is provided as a continuous process by pulling the core through the coating solution, using a pulling speed suitable for providing a coating thickness of &#x3b4;-IOOthe filler is selected from silica, titanium dioxide, barium sulphate, carbon and mixtures thereof; the elastomer comprised in the core and the elastomer comprised in the coating solution are independently selected from poly(dimethyl) siloxanes, polyethylene vinyl acetates (EVAs), polyurethanes (PUs), polyhydroxyethyl methacrylates (PHEMAs) and polymethyl methacrylates (PMMAs).

Method for modifying release of a therapeutically active agent from an elastomeric matrix

The invention relates to a method for contraception and for reducing menstrual problems and inducing amenorrhea, wherein an intrauterine delivery device is used for the controlled release of a combination of progestogen or a drug having a progestogenic activity and at least one therapeutically active substance capable of preventing or suppressing abnormal and/or irregular endometrial bleeding over a prolonged period of time.

Intrauterine delivery system for contraception

A method for determining the concentration of a light-emitting compound. An electric pulse is applied to a pair of current-delivering electrodes immersed in an electrolyte having positioned between the electrodes a conductor not in electronic contact with electrodes. As a result of the applied electric pulse, the light-emitting compound in electronic contact with the conductor luminesces in which the emitted light is measured and used to quantify the light-emitting compound.

Method for luminescence measurements

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Paimio, Finland

Jyrki Pihlaja