Genentech, Inc.

Jyoti Asundi

Paul Polakis

Ron Firestein

Suzanna Clark

William Mallet

Chie Sakanaka

Christine Tan

Peter Chang

Youjun Chen

Rayna Takaki Venook

Robert F Kelley

Krista Maureen McCutcheon

The invention provides anti-Ly6E antibodies, immunoconjugates and methods of using the same.

Anti-Ly6E antibodies and methods of use

The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.

Anti-PMEL17 antibodies and immunoconjugates

The invention provides anti-Ly6E antibodies, immunoconjugates and methods of using the same. In some embodiments, the anti-Ly6E antibodies comprise heavy chain HVRs comprising the amino acid sequences of SEQ ID NOs: 32-34 and/or light chain HVRs comprising the amino acid sequences of SEQ ID NOs: 29-31.

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

Compositions and methods for the diagnosis and treatment of tumor

The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent is provided, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10. In some embodiments, the cytotoxic agent is a nemorubicin derivative.

Anti-ETBR antibodies and immunoconjugates

The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent is provided, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10. In some embodiments, the cytotoxic agent is a pyrrolobenzodiazepine.

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Foster City, CA, United States of America

Jyoti Asundi