National Health Research Institutes

Jyh-Haur Chern

Yen-Chun Lee

Chung-Chi Lee

Yu-Sheng Chao

Shin-Ru Shih

Tsu-An Hsu

Chia-Liang Tai

Iou-Jiun Kang

Li-Wen Wang

Chih-Shiang Chang

Chiung-Tong Chen

Kak-Shan Shia

Shu-Jen Chen

Ming-Chu Hsu

Wen-Tai Li

Chung-Ming Chang

Feng-Shiun Shie

Yen-Shian Wu

Sheng-Ju Hsu

Yueh Andrew Yueh

Compounds useful for treating hepatitis C virus infection. The compounds are of formula (I): wherein A, B, C, D, R, R, R, R, R, R, R, R, R, R, R, R, m, n, p, q, r, t, u, and v are defined herein. Also disclosed is a method for treating hepatitis C virus infection with these compounds.

Proline derivatives

A method for treating a neurodegenerative disorder. The method includes administering to a subject in need thereof an effective amount of one or more thiourea compounds of formula (I) or (II): Each variable in formula (I) or (II) is defined herein. Also disclosed is use of these thiourea compounds to reduce microglia-mediated neuro-inflammation or enhancing microglial phagocytosis of A&#x3b2;.

Treatment of neurodegenerative disorders with thiourea compounds

A compound of the following formula: in which R, R, R, U, V, T, W, X, Y, Z, m, n, p, x, y, and z are as defined herein. Also disclosed are (1) a pharmaceutical composition containing such a compound, and (2) a method for treating Hepatitis C virus infection using such a compound.

Hepatitis C virus inhibitors

Imidazolidinone and imidazolinethione compounds of formula (I): wherein R, R, R, A, A, X, Y, Z, m, n, p, x, and y are defined herein. Also disclosed is a method of treating hepatitis C virus infection with these compounds.

Imidazolidinone and imidazolidinethione derivatives

Thiourea compounds of the following formula: wherein n, R, R, R, A, A, X, Y, and Z are defined herein. Also disclosed is a method of treating hepatitis C virus infection with these compounds.

Thiourea derivatives

This invention relates to compounds of the following formula: in which R, R, A, A, X, Y, m, n, p, x and y are as defined herein, pharmaceutical compositions comprising the compounds and use of the compounds in treating enterovirus infection.

Imidazolidinone compounds

Compounds of the following formula: in which R, R, A, A, X, Y, m, n, p, x and y are as defined herein. Also disclosed are pharmaceutical compositions each containing one or more of these compounds, and use thereof in treating enteroviral infection.

Anti-enterovirus compounds

Growing community of inventors

Taipei, Taiwan

Jyh-Haur Chern