Theravance, Inc.

Alios Biopharma, Inc.

Sri International

Vertex Pharmaceuticals, Inc.

Thervance, Inc.

Jyanwei Liu

Junning Lee

Martin Sheringham Linsell

Michael Robert Leadbetter

Leonid Beigelman

Vladimir Serebryany

Paul Ross Fatheree

Daniel D Long

Seok-Ki Choi

Roland Gendron

Daniel Marquess

Adam Aaron Goldblum

S Derek Turner

Masato Tanabe

Wan-Ru Chao

Luigi Anzalone

Richard H Peters

Young Chun Jung

Kenneth J Ryan

John G Johansson

Shereen Ibrahim

Daniel G Genov

Peter Jamison Rose

Cavan McKeon Bligh

Jamison Rose

Cavan McKeon

Disclosed herein are methods of preparing a nucleoside analog, Compound (I): or a pharmaceutically acceptable salt thereof, which is useful in treating diseases and/or conditions such as viral infections, and intermediates thereof.

Methods of preparing substituted nucleoside analogs

Disclosed herein are methods of preparing a nucleoside analog (I) by a reaction that includes an intermediate (GG):  Nucleoside analog (I) is useful in treating diseases and/or conditions such as viral infections.

Disclosed herein are methods of preparing a phosphorothioate nucleotide analog, which are useful in treating diseases and/or conditions such as viral infections.

Methods of preparing substituted nucleotide analogs

Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.

Process for preparing glycopeptide phosphonate derivatives

The invention provides novel indazole-carboxamide 5-HTreceptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HTreceptor activity, and processes and intermediates useful for preparing such compounds.

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Disclosed are hydrochloride salts of telavancin having a chloride ion content of from about 2.4 wt. % to about 4.8 wt. %. The disclosed salts have improved stability during storage at ambient temperatures compared to other hydrochloride salts. Also disclosed are processes for preparing such salts.

Hydrochloride salts of a glycopeptide phosphonate derivative

Syntheses of steroids such as 3-hydroxy-7&#x3b1;-methyl-21-[2'-methoxy-4&#x2032;-(diethylaminomethyl)-phenoxy]-19-norpregna-1,3,5(10)triene citrate ('SR 16234') and analogs thereof are provided, wherein 21-hydroxy-19-norpregna-4-en-3-one serves as a starting material or intermediate. The latter compound may be readily prepared from estrone-3-methyl ether. Certain intermediates in these syntheses also have value as therapeutic agents, for example in the treatment of prostate disorders such as prostatic cancer.

Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one

The invention provides 8-azabicyclo[3.2.1 ]octyl intermediates useful for the preparation of 5-HTreceptor agonist compounds. The invention also provides processes for the preparation of such useful intermediates.

Disclosed are processes for preparing glycopeptide antibiotic derivatives having an amino-containing side chain. The multi-step process is conducted in a single reaction vessel without isolation of intermediate reaction products.

Process for preparing glycopeptide derivatives

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Sunnyvale, CA, United States of America

Jyanwei Liu