Merck + Co., Inc.

Jwu-Sheng Tung

Paul M Keller

George E Mark, Iii

Anthony J Conley

Beth A Arnold

Simon W Law

Melvin Silberklang

Linda O Palladino

A process of purifying target molecules is described that involves the selection of ligands based on identifying, in real time, association and dissociation constants with a given target molecule; using this information to select at least one ligand that exhibit predetermined association and dissociation constants with a given target molecule; anchoring a quantity of ligand to an activated solid support; contacting a quantity of target molecules with the anchored ligand(s); removing low affinity target molecules from anchored ligand and eluting particularly pure target molecules.

Large scale affinity chromatography of macromolecules

A protein having a molecular weight of about 6,000 daltons which is biologically active in the inhibition of Factor Xa during the blood coagulation cascade, a method for producing the protein, methods for inhibiting blood coagulation using the protein, and suitable pharmaceutical compositions.

Antistasin derived anticoagulant protein

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Cranbury, NJ, United States of America

Jwu-Sheng Tung