Softhale Nv

Invox Belgium Nv

Advanced Display Technology Ag

Aworth, Chris

Bartels, Frank

Rawert, Jürgen

Jürgen Rawert

Frank Bartels

Andriy Bitman

Dieter Jerosch

Oliver Müller-Marc

Jan Torsten Tews

Steven Dudley

Andriy Dipl-Ing Bitman

Jan-Torsten Tews

The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to an inhalation device having improved flow characteristics. A inhalation device for medically active liquids (F) for generation of an aerosol comprises a housing (), inside this housing () a reservoir () for storing a liquid (F), a pumping device with a hollow cylinder () providing a pumping chamber () for the generation of a pressure inside said pumping chamber (), wherein the pumping chamber is fluidically connected with the reservoir () via an inlet check valve () which blocks in direction of the reservoir (), a riser pipe () which can be received with at least one reservoir-facing, interior end (A) in said hollow cylinder (), and a nozzle () which is connected liquid-tight to an exterior end (B) of the riser pipe (), wherein the volume of the pumping chamber () is changeable by means of relative motion of the cylinder () to the riser pipe (), and is characterised in that the riser pipe () is immobile and firmly attached to the housing () and to the nozzle (), whereas the hollow cylinder () is moveable relative to the housing () and to the nozzle (). The invention also discloses a method for the generation of an aerosol of a medically active liquid (F) by means of an inhalation device.

Inhalation device and method

Inhaler

The invention relates to the field of nozzles for inhalation devices for liquids. In particular, the invention relates to a nebulizing nozzle for an inhalation device, suitable for the generation of an aerosol of a medically active liquid, and to inhalation devices comprising such nozzle. Such nozzle () for an inhalation device for medically active liquids (F, F, F) for generation of an aerosol has a main axis (Z) and at least three ejection channels (A,B,C,D) adapted to eject liquid (F, F, F) along respective ejection trajectories, wherein at least two collision points (X, X) are provided at which at least two of said ejection trajectories intersect with one another, and/or wherein further, all ejection angles (A, A, A) at which the individual trajectories leave the nozzle () are identical, or at least one of said ejection angles (A, A, A) differs from the other ejection angles (A, A, A).

Multiliquid-nozzle

The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to a fixture for a nebulizing nozzle to be used in such an inhalation device. A nozzle fixing assembly () for an inhalation device, comprising an elastically deformable seal element (), having a continuous opening () capable of receiving a nozzle body (), said seal element () and said nozzle body () each having a high pressure side (A,A) and an outlet side (B,B); and a pressure element () with a high pressure side (A), said side being arranged to face the high pressure side (A) of the seal element (); wherein (i) the high pressure side (A) of the seal element () is substantially flat, and (ii) the high pressure side (A) of the pressure element () is chamfered in a way that, in the assembled state, the distance between these high pressure sides (A,A) is higher in a central region (C) than in a peripheral region (P).

Nozzle fixture for an inhalation device

The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to an inhalation device having a nebulizing nozzle, and to a method for the generation of an aerosol of a medically active liquid by means of such inhalation device. An inhalation device comprises a housing (), inside this housing () at least one reservoir () for storing a liquid (F, F, F), at least one pumping unit with at least one pumping chamber (A,B) for generation of a pressure inside said pumping chamber (A,B), at least one riser pipe (A,B) which can be received with at least one reservoir-facing, interior end (A',B′) in said pumping chamber (A,B), and a nozzle () which is connected to an exterior end (A″,B″) of the riser pipe (A,B), wherein the interior volume of the at least one pumping chamber (A,B) is changeable by means of relative motion of the pumping chamber (A,B) to the riser pipe (A,B), and wherein the at least one riser pipe (A,B) is immobile and firmly attached to the housing () or to the nozzle (), and the at least one pumping chamber (A,B) is moveable relative to the housing () or to the nozzle (), wherein further, the nozzle () has a main axis (Z) and at least three ejection channels (A,B,C,D) adapted to eject liquid (F, F, F) along respective ejection trajectories, wherein at least one collision point (X, X, X) is provided at which at least two of said ejection trajectories intersect with one another.

Inhalation device with multiliquid-nozzle and method

The invention relates to the field of inhalation methods and inhalation devices for liquids. In particular, the invention relates to an inhalation method using an inhalation device having a nebulizing nozzle, and to a method for the generation of an aerosol of an aqueous formulation comprising pirfenidone by means of such inhalation device.

Aerosol delivery of pirfenidone

The invention relates to a valve, in particular for a device for administering a liquid medicament, with a valve body () which has an interior () for receiving a liquid (), wherein the valve body () has a liquid inlet () and an opposite liquid outlet () which both open into the interior (), wherein the interior () accommodates a large number of micro channels () which extend in connection direction (x) between the liquid inlet () and the liquid outlet (). A corresponding device for administering a liquid medicament is also described.

Valve, in particular for a device for administering a liquid medicament, and a corresponding device for administering a liquid medicament

The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to an improved seal construction for an inhalation device having a nebulizing nozzle and a piston which moves relative to a pumping chamber in order to generate pumping pressure and to an inhalation device comprising such seal.

Seal for an inhalation device

The inhalation device for medically active liquids (F) for generation of an aerosol comprises a housing (), a reservoir (), a pumping device with a pumping chamber (), and a nozzle (), wherein the interior volume of the pumping chamber () is changeable by means of linear relative motion of the pumping chamber to the riser pipe (). Said linear relative motion can be effected by a relative rotation of a rotatable part (A) which is part of, or connected to, the housing () with respect to a second part (B) of said housing (), in that said relative rotation can be transferred by means of a gear mechanism into said relative translational motion. A means for the storage of potential energy () is provided which is chargeable by means of said relative rotation, and wherein said energy is releasable to said pumping device when released by activation of a release means. A blocking device is provided which is adapted to block activation of the release means and/or release of the means for the storage of potential energy () during rotation of the rotatable part (A) and/or during loading of the means for the storage of potential energy (). Also, a method for the prevention of undesired emission of medically active liquid or aerosol from an inhalation device is disclosed.

Blocking device

The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to a pumping chamber for such an inhalation device. A pumping unit for an inhalation device for medically active liquids for generation of an aerosol comprises a tubular member (), a check valve (), and a counter piece, said counter piece being configured to receive at least a downstream segment of said tubular member () and having an interior volume, wherein upstream of said tubular member (), a reservoir () can be fluidically connected with said tubular member (), and downstream of said counter piece, a nozzle unit () can be fluidically connected with said counter piece, and wherein the tubular member () comprises an upstream section, a downstream section, and the check valve () which is positioned between the upstream section and the downstream section, such that a pumping chamber with a pumping chamber volume is defined which comprises the volume of the downstream section of the tubular member () and said interior volume of the counter piece, and wherein tubular member () and the counter piece can move relatively to one another, such that the pumping chamber volume is variable. The tubular member () comprises at least two mechanically distinct parts (A,B), wherein a first part (A) provides said upstream section, and a second part (B) provides said downstream section, and the first part (A) and the second part (B) are connected to each other such as to form an interface section (C) serving as a valve chamber (B) for the valve ().

Flexible pumping chamber

An atomiser, in particular an inhaler, for atomising a liquid active agent to form an aerosol, having, inter alia, an active agent reservoir, an atomiser nozzle and a pump arrangement, wherein a suction side of the pump arrangement leads into the active agent reservoir and a pressure side of the pump arrangement leads into the atomiser nozzle, and wherein the pump arrangement has a plunger that can be adjusted in a cylinder in the axial direction of the cylinder. A corresponding method is also described.

Atomiser, in particular inhaler, for atomising a liquid active agent to form an aerosol and a corresponding method

The invention relates to a valve, in particular for a device for administering a liquid medicament, with a valve body which has an interior for receiving a liquid, wherein the valve body has a liquid inlet and an opposite liquid outlet which both open into the interior, wherein the interior accommodates a large number of micro channels which extend in a connection direction between the liquid inlet and the liquid outlet. A corresponding device for administering a liquid medicament is also described.

The present invention provides for a method for the treatment of a viral disease, disorder or condition in a subject, the method comprising the step of administering to said subject a medically active liquid in nebulized form by inhalation, wherein the medically active liquid comprises remdesivir or a pharmaceutically acceptable salt thereof and wherein the medically active liquid is administered in nebulized form using an inhalation device.

Growing community of inventors

Cologne, Germany

Jürgen Rawert