Legochem Biosciences, Inc.

Ligachem Biosciences Inc.

Juyuel Baek

Yong Zu Kim

Ho Young Song

Ju Young Lee

Jeiwook Chae

Yeong Soo Oh

Chul-Woong Chung

Sung Min Kim

Hyo Jung Choi

Kyung Eun Park

Su In Lee

Hyoungrae Kim

Ji Hye Oh

Hyeun Joung Lee

Yun Hee Park

Yun-Hee Park

The present invention relates to a pyrrolobenzodiazepine dimer prodrug and a ligand-linker conjugate compound thereof, a composition containing these, and therapeutic use thereof particularly as an anticancer drug. The stability of the compounds themselves and the stability thereof in plasma are excellent and the compounds are advantageous in terms of manifestation of toxicity, and thus the compounds are industrially useful in that it is possible to target proliferative diseases such as cancer, to perform a specific treatment, to maximize the drug efficacy, and to minimize the occurrence of side effects.

Pyrrolobenzodiazepine dimer prodrug and ligand-linker conjugate compound of the same

The present disclosure relates to pyrrolobenzodiazepine dimer prodrugs and ligand-linker conjugates thereof. The present disclosure also relates to compositions and uses of said prodrugs and conjugates.

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Daejeon, South Korea

Juyuel Baek