Bam Bundesanstalt Fuer Materialforschung Und-pruefung

Bam Bundesanstalt Fur Materialforschung Und-prufung

Jutta Pauli

Georg Berger

Christian Jäger

Andrea Spitzer

Renate Gildenhaar

Heidi Marx

The present invention relates to an X-ray amorphous-crystalline material with high solubility which can be used as a bioactive bone replacement material and as a substrate material in biotechnology. The new material comprising crystalline and X-ray amorphous phases is characterized in that according toP-NMR measurements, it contains Q-groups of orthophosphate and Q-groups of diphosphate, the orthophosphates or Q-groups making up 70 to 99.9% by weight relative to the total phosphorus content of the finished material and the diphosphates or Q-groups making up 0.1 to 30% by weight relative to the total phosphorus content of the finished material, and that according to X-ray diffractometric measurements and relative to the total weight of the finished material, 30 to 99.9% by weight of a main crystal phase consisting of CaKNa(PO), where x=0.1 to 0.9, is contained in the bone replacement material and 0.1 to 20% by weight of a substance selected from the group consisting of NaCaPO, KCaPO, CaPOand mixtures thereof is contained as a secondary crystal phase, the X-ray amorphous phases contained besides the main crystal phase jointly making up 0.1 to 70% by weight relative to the total weight of the finished material.

Bone replacement material comprising crystalline phases

The present invention relates to an X-ray amorphous-crystalline material with high solubility which can be used as a bioactive bone replacement material and as a substrate material in biotechnology. The new material comprising crystalline and X-ray amorphous phases is characterized in that according toP-NMR measurements, it contains Q-groups of orthophosphate and Q-groups of diphosphate, the ortho-phosphates or Q-groups making up 70 to 99.9% by weight relative to the total phosphorus content of the finished material and the diphosphates or Q-groups making up 0.1 to 30% by weight relative to the total phosphorus content of the finished material, and that according to X-ray diffractometric measurements and relative to the total weight of the finished material, 30 to 99.9% by weight of a main crystal phase consisting of CaKNa(PO), where x=0.1 to 0.9, is contained in the bone replacement material and 0.1 to 20% by weight of a substance selected from the group consisting of NaCaPO, KCaPO, CaPOand mixtures thereof is contained as a secondary crystal phase, the X-ray amorphous phases contained besides the main crystal phase jointly making up 0.1 to 70% by weight relative to the total weight of the finished material.

Bone replacement material comprising crystalline and X-ray amorphous phases

The present invention relates to a material with orthophosphate and having a high solubility which can be used as a bioactive bone replacement material and as a substrate material in biotechnology. According toP-NMR measurements, the new material comprises Q-groups of orthophosphate and Q-groups of diphosphate, the orthophosphates or Q-groups making up 65 to 99.9% by weight relative to the total phosphorus content of the finished material and the diphosphates or Q-groups making up 0.1 to 35% by weight relative to the total phosphorus content of the finished material, and wherein according to X-ray diffractometric measurements and relative to the total weight of the finished material, 35 to 99.9% by weight of a main crystal phase consisting of CaNa(PO), CaK(PO), mixtures thereof or mixed crystals according to the general formula CaKNa(PO), where x=0 to 1, is contained in the bone replacement material and 0.1 to 25% by weight of a substance selected from the group consisting of NaCaPO, KCaPO, CaPOand mixtures thereof is contained as a secondary crystal phase, and the X-ray amorphous phases contained besides the main crystal phase jointly make up 0.1 to 65% by weight.

Bone replacement material with orthophosphate

The present invention relates to a powder mixture for resorbable calcium phosphate biocements, which mixture consists of 40&#x2013;99% by volume of powder having a particle size of 0.1&#x2013;10 &#x3bc;m, 1&#x2013;20% by volume of powder having a particle size of 10&#x2013;43 &#x3bc;m and 0&#x2013;59% by volume of powder having a particle size of 43&#x2013;315 &#x3bc;m, which powder is obtained by grinding the spontaneously crystallizing melts of a material comprising crystalline and X-ray amorphous phases, which material

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Berlin, Germany

Jutta Pauli