Biothera Institut Gmbh

Novartis Ag

Oregon Health & Science University

Technische Universitat Munchen

Mallinckrodt Pharmaceuticals Ireland Limited

Centre Hospitalier Régional Universitaire De Lille

Medvet Science Pty Ltd

Université Victor Segalen—bordeaux 2

University of Heidelberg

Justus Duyster

Brian Jay Druker

Timothy Charles Hughes

Robert Zeiser

Amie Corbin

Roland Mertelsmann

Petya Apostolova

Maximiliano S Perez

François-Xavier Mahon

Sascha Lange

Marie Follo

Martin Mueller

Thibaut Leguay

Claude Preudhomme

Zbigniew Rudzki

Susan Branford

Catherine Roche Lestienne

Gérald Marit

Andreas Hochhaus

Sebastian Kreil

Christophe Barthe

Christian Peschel

The present invention relates to a method comprising the steps of provision of a sample derived from a blood sample of a subject that has received a checkpoint-inhibitor therapy and is suspected of developing or has developed symptoms of immune-related adverse events (irAE), adding a photosensitizing agent to the sample, and subjecting the sample to irradiation, which preferably generates immunoregulatory NK cells in said sample. In embodiments, the photosensitizing agent is 8-methoxypsoralen and/or the irradiation is UVA irradiation. In another aspect, the invention relates to immunoregulatory NK cells obtained from a method comprising the steps of provision of a sample derived from an isolated blood sample of a subject, adding a photosensitizing agent to the sample, and subjecting the sample to irradiation. Furthermore, the invention encompasses immunoregulatory NK cells for use in the treatment and/or prevention of irAE in a subject that has received a checkpoint-inhibitor therapy.

Method for generating immunoregulatory cells in a blood-derived sample

A method for setting up an apparatus () for biological processes (), in which process parameters are specified for a plurality of biological processes () with computer assistance, that for each biological process () a process state is automatically captured, that the particular process state is evaluated using a specified objective with computer assistance, and that from the evaluations the apparatus () is set up, with computer assistance, through specification of learned set-up parameters. In addition, an apparatus () for biological processes () is provided with which the proposed method can be carried out in a particularly advantageous manner.

Method for setting up an apparatus for biological processes and apparatus for biological processes

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Freiburg, Germany

Justus Duyster