St. Jude Children's Research Hospital

Justine Cunningham

Martine F Roussel

Frederique Zindy

Richard Jay Smeyne

Neil Segil

Ping Chen

Non-human animals that have been manipulated so as not to express a functional p19 and p27 proteins are described. One particular non-human animal exemplified is a p19 -double null, p27 -double null mouse. Such knockout mice exhibit bradykinesia, proprioceptive abnormalities, seizure-like activity, and generally die 14-24 days after birth. In addition, mammalian cells having the p19 -double null, p27 -double null genotype are characterized. Methods of making and using the non-human knockout animals and cells are disclosed.

Cells that lack p19ink4d and p27kip1 activity and methods of use thereof

Non-human animals that have been manipulated so as not to express a functional p19,and p27,proteins are described. One particulat non-human animal exemplified is a p19,-double null, p27,-double null mouse. Such knockout mice exhibit bradykinesia, proprioceptive abnormalties, seizure-like activity, and generally die 14-24 days after birth. In addition, mammalian cells having the p19,-double null, p27,-double null genotype are characterized. Methods of making and using the non-human knockout animals and cells are disclosed.

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Memphis, TN, United States of America

Justine Cunningham