Hoffmann-la Roche Inc.

Astrazeneca Ab

Justin Warne

Guy Georges

Frederick Arthur Brookfield

Stefan Scheiblich

Edward Andrew Boyd

Wolfgang Von Der Saal

Petra Rueger

Stefan Weigand

Matthias Rueth

George Cockerill

Bernhard Goller

James Lumley

Christine Schuell

Helena Dennison

Keith Spencer

Sabine Huensch

Use of a benzodiazepine of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in treating or preventing a hepatitis C infection, wherein: &#x2014;Rrepresents Calkyl, aryl or heteroaryl; &#x2014;Rrepresents hydrogen or Calkyl; &#x2014;each Ris the same or different and represents halogen, hydroxy, Calkyl, Calkoxy, Calkylthio, Chaloalkyl, Chaloalkoxy, amino, mono(Calkyl)amino, di(Calkyl)amino, nitro, cyano, &#x2014;COR', &#x2014;CONR&#x2032;R&#x2033;, &#x2014;NH&#x2014;CO&#x2014;R&#x2032;, &#x2014;S(O)R&#x2032;, &#x2014;S(O)R&#x2032;, &#x2014;NH&#x2014;S(O)R&#x2032;, &#x2014;S(O)NR&#x2032;R&#x2033; or &#x2014;S(O)NR&#x2032;R&#x2033;, wherein each R&#x2032; and R&#x2033; is the same or different and represents hydrogen or Calkyl; &#x2014;n is from 0 to 3; &#x2014;Rrepresents hydrogen or Calkyl; &#x2014;Rrepresents Calkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(Calkyl)-, heteroaryl-(Calkyl)-, carbocyclyl-(Calkyl)-, heterocyclyl-(Calkyl)-, aryl-(Chydroxyalkyl)-, heteroaryl-(Chydroxyalkyl)-, carbocyclyl-(Chydroxyalkyl)-, heterocyclyl-(Chydroxyalkyl)-, aryl-C(O)&#x2014;C(O)&#x2014;, heteroaryl-C(O)&#x2014;C(O)&#x2014;, carbocyclyl-C(O)&#x2014;C(O)&#x2014;, heterocyclyl-C(O)&#x2014;C(O)&#x2014; or &#x2014;XR; &#x2014;X represents &#x2014;CO&#x2014;, &#x2014;S(O)&#x2014; or &#x2014;S(O)&#x2014;; and &#x2014;Rrepresents Calkyl, hydroxy, Calkoxy, Calkylthio, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(Calkyl)-, heteroaryl-(Calkyl)-, carbocyclyl-(Calkyl)-, heterocyclyl-(Calkyl)-, aryl-(Calkyl)-O&#x2014;, heteroaryl-(Calkyl)-O&#x2014;, carbocyclyl-(Calkyl)-O&#x2014;, heterocyclyl-(Calkyl)-O&#x2014; or &#x2014;NR&#x2032;R&#x2033; wherein each R&#x2032; and R&#x2033; is the same or different and represents hydrogen, Calkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, aryl-(Calkyl)-, heteroaryl-(Calkyl)-, carbocyclyl-(Calkyl)- or heterocyclyl-(Calkyl)-. 

Benzodiazepine derivatives for treating hepatitis C infection

Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, pharmaceutical compositions containing them, as well as the use of the above-mentioned compounds in the treatment, control or prevention of illnesses such as cancer.

Phthalazinone derivatives

Growing community of inventors

London, United Kingdom

Justin Warne