Warner-lambert Company

Pfizer Corporation

Other

Warner-dambert Company LLC

Justin Stephen Bryans

David Christopher Horwell

David Juergen Wustrow

Clare Octavia Kneen

Patrick Stephen Johnson

David Clive Blakemore

Alan Daniel Brown

Charlotte Alice Louise Lane

Andrew John Thorpe

Thomas Ryckmans

Jean-Marie Receveur

Po-wai Yuen

Paul Alan Glossop

Simon John Mantell

Russell Andrew Lewthwaite

Mark Edward Bunnage

Alan Stobie

Giles Stuart Ratcliffe

Andrew I Morrell

Sophie Caroline Williams

Thomas R Belliotti

Lee Richard Roberts

Thomas Capiris

Simon Andrew Osborne

Ihoezo Victor Ekhato

Lawrence D Wise

Andrew Douglas Baxter

Johannes Hartenstein

David James Rawson

Jacob Bradley Schwarz

Kevin Neil Dack

Augustine Tobi Osuma

Leonard Theodore Meltzer

Robert Michael Schelkun

Julie Newman

Rong Ling

Simmon John Mantell

Robert Duncan Armour

Toby James Underwood

John Colm O'Toole

Charlotte Alice Lane

Thomas Richard Belliotti

Po-Wai Yuen

Lawrence David Wise

Helen Janet Mason

The present invention provides compounds of formula (I), or pharmaceutically acceptable derivatives thereof wherein the variables Z, Q, Ring A, V, X, Y and Y' are as defined herein, and pharmaceutical compositions comprising these compounds. The compounds of formula (I) and pharmaceutical compositions comprising them are useful for treating a disorder for which a V1a antagonist is indicated, in particular, dysmenorrhoea.

Compounds useful in therapy

Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein:

Triazolyl piperidine arginine vasopressin receptor modulators

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions. 

Phenylaminoethanol derivatives as &#x3b2;2 receptor agonists

Triazole derivatives which inhibit vasopressin antagonistic activity

A compound of formula (I), or a pharmaceutically acceptable derivative, wherein A, B, V, W, X, Y, and Z are as defined herein; pharmaceutical compositions thereof; and uses thereof.

Triazole compounds useful in therapy

The invention relates to indole derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The indole derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

Indole derivatives useful for the treatment of diseases

The invention provides a new use of compounds for formula 1 or 1A or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment of insomnia and related disorders. 

Gabapentin analogues for sleep disorders

The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), and inflammation, especially arthritis. A pharmaceutical composition containing a compound of the invention as well as methods of preparing the compounds and novel intermediates useful in the preparation of the final compounds are included.

Cyclic amino acids and derivatives thereof useful as pharmaceutical agents

A compound of formula (I), or a pharmaceutically acceptable derivative thereof, wherein A, B, V, W, X, Y, and Z are as defined herein; pharmaceutical compositions thereof; and uses thereof.

The invention provides compounds of formula (I), the pharmaceutically acceptable salts and solvates thereof, wherein A, B, R, R, and Rare as defined herein; pharmaceutical compositions thereof; combinations thereof; and uses thereof as vasopressin Vantagonists.

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

2-amino-pyridine derivatives useful for the treatment of diseases

A method is provided for making an enantiomerically pure compound of the formula: in which R and R' represent C1?C10 alkyl, C2?C10 alkenyl or C3?C10 cycloalkyl and the wedges signify (S)- or (R)-stereochemistry, the substituents in compound (II) being trans. Conjugate addition is carried out between an organometallic nucleophile that provides a group R as defined above and (R)-4-acetoxycyclopent-2-en-1-one, (S)-4-acetoxycyclopent-2-en-1-one or a similar compound in which acetoxy is replaced by another leaving group to give, e.g. in the case of the acetoxy compound, a trans 3,4-disubstituted addition product of formula III or IV; The acetyl group is eliminated from the addition product to give an (R)- or (S)-4-alkyl or 4-alkenyl cyclopent-2-en-1-one the compound of formula is then to be hydrogenated to give a cyclopentanone of formula (I) or conjugate addition of a second organometallic nucleophile that provides a group R&#x2032; as defined above to the compound of the above formula may be carried out to give a trans 3,4-disubstituted addition product of formula (II). One of the above compounds may be converted e.g. via an intermediate (XV)-(XVIII) (in which the substituents R and R&#x2032; and the wedges have the meanings indicated above) to a gabapentin analogue of one of the formulae shown below: in which the substituents R and R&#x2032; and the wedges also have the meanings indicated above.

Cyclic ketones, their preparation and their use in the synthesis of amino acids

The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), inflammation especially arthritis, sleep disorders, premenstrual syndrome, and hot flashes. The invention provides novel routes to synthesize steroselectively analogs of gabapentin (Neurontin&#xae;) of Formulas (I), (II), (III) and (IV) wherein R is C-Calkyl or C-Ccycloalkyl and pharmaceutically acceptable salts thereof.

Method for the stereoselective synthesis of cyclic amino acids

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Balsham, United Kingdom

Justin Stephen Bryans