Johns Hopkins University

Justin Sacks

Hai-Quan Mao

Sashank Reddy

Xiaowei Li

Russell E Martin

Gerald Brandacher

Xuesong Jiang

Georgia C Yalanis

Brian Honewee Cho

Ji Suk Choi

Kevin Feng

Russell Martin

The presently disclosed composition and methods are provided for a nanofiber-hydrogel composite containing adipose cell binding moieties. A method for healing a soft tissue defect can include applying an adipose cell-binding composite material to a soft tissue defect in combination with exogenous adipose-derived cells or endogenous cells recruited from the surrounding tissue.

Mesenchymal cell-binding composite material for tissue restoration

A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

Composite material for tissue restoration

The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.

Fiber-hydrogel composite surgical meshes for tissue repair

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Baltimore, MD, United States of America

Justin Sacks