Johns Hopkins University

University of Pennsylvania

Vanderbilt University

Justin R Bailey

Stuart Campbell Ray

James E Crowe, Jr

George M Shaw

Andrew I Flyak

Drew Weissman

Robert Siliciano

David Lee Thomas

Joel Blankson

Michel Anand Chattergoon

Ashwin Balagopal

Ramy El-Diwany

The present invention relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof.

Nucleoside-modified mRNA-lipid nanoparticle lineage vaccine for hepatitis C virus

The present disclosure relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present disclosure provides a composition comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof.

Hepatitis C virus gene sequences and methods of use therefor

Three proteins, BCL-G (BCL2L14), CMPK2, and LAMP3, were discovered to independently restrict HIV-1 replication both in-vivo and in-vitro. Methods are described wherein subjects are given an effective amount of a pharmaceutical composition comprising a protein selected from the group consisting of BCL-G, CMPK2, LAMP3, functional parts thereof, recombinant proteins thereof, and combinations thereof, for the purpose of treating or preventing HIV.

Antiviral proteins and their uses in therapeutic methods

Growing community of inventors

Timonium, MD, United States of America

Justin R Bailey