Gilead Pharmasset LLC

Roche Palo Alto LLC

Hoffmann-la Roche Inc.

Gilead Sciences, Inc.

F. Hoffmann-la Roche Ag

Justin Philip Vitale

Xianqing Shi

Lawrence Emerson Fisher

Robert William Scott

Martin Gerald Teresk

Jared Wayne Evans

Kenneth Stanley Matthews

Michaelangelo Scalone

Arthur Meili

Alexandra Formella

Kieran Durkin

Jiang Zhu

Michelangelo Scalone

Hans Iding

Byoung-Kwon Chun

Charles Alois Dvorak

Keshab Sarma

Bruce Ross

Suguna Rachakonda

Jean-Michel Adam

Christophe Pfleger

Eric Roy Humphreys

Shaoning Wang

Johann Chan

Qingwu Jin

Pankaj D Rege

Daniel Fishlock

Steven D Axt

Quingwu Jin

Marian Zajac

Eric R Humphreys

The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula I.

Synthesis of antiviral compound

The present invention is concerned with a novel process for the preparation of a compound of formula I and its hydrates  The compounds of formula I and the corresponding hydrates are pharmaceutically active substances.

(3,4-dichloro-phenyl)-((S)-3-propyl-pyrrolidin-3-yl)-methanone hydrochloride and manufacturing processes

Methods for producing a compound of formula k1 or k2 by reducing a dihydronapthalene amide compound of formula i with hydrogen gas in the presence of a ruthenium catalyst of formula j1 or j2Ru(Z)(L)&#x2003;&#x2003;j1;Ru(E)(E')(L)(D)&#x2003;&#x2003;j2;wherein m, n, Ar, Y, RE, E&#x2032;, D, Z and L are as defined herein.

Process for synthesis of amino-methyl tetralin derivatives

The present disclosure relates to processes for preparing dronedarone or pharmaceutically acceptable salts thereof.

Process for preparing dronedarone and salts thereof

The present process provides an improved method for the preparation of 4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydrofuran-2-yl)-1H-pyrimidin-2-one of the formula (IV) which is a potent inhibitor of Hepatitis C Virus (HCV) NS5B polymerase. 

Preparation of nucleosides ribofuranosyl pyrimidines

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San Mateo, CA, United States of America

Justin Philip Vitale