Aileron Therapeutics, Inc.

Justin Noehre

Rosana Kapeller-Libermann

Tomi K Sawyer

Huw M Nash

Noriyuki Kawahata

Jia-Wen Han

Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an &#x3b1;,&#x3b1;-disubstituted amino acid, or may comprise a crosslinker linking the &#x3b1;-positions of at least two amino acids or at least one of said two amino acids may be an &#x3b1;,&#x3b1;-disubstituted amino acid. Further included is the targeting of components of the Wnt signaling pathway such as the Tcf4-/3-catenin complex.

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Cambridge, MA, United States of America

Justin Noehre