Wisconsin Alumni Research Foundation

Justin Murray

Samuel Helmer Gellman

Matthew Woll

Jonathan R Lai

Disclosed are polypeptide compounds containing at least one residue comprising a cyclically-constrained &#x3b3;-amino acid residue. The compounds have the formulawhere A is a hydrogen, hydroxy, amino- or carboxy-protecting group, Y is a single bond or a prolyl-containing linking group, and X and Y are &#x3b3;-amino acid residues, provided that one of X or Y is a conformationally-restrained &#x3b3;-amino acid residue, and 'a,' 'c,' and &#x201c;d&#x201d; are positive integers. The compounds find use as non-enzymatically degradable probes to mimic protein behavior in solution.

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Madison, WI, United States of America

Justin Murray