Western Digital Technologies, Inc.

Sandisk Technologies Inc.

Justin Kinney

Daniel Bedau

Tung Thanh Hoang

Wen Ma

Disclosed herein are devices, systems, and methods for controlling the movement of at least one molecule in a first fluid having a first viscosity. The system includes a fluid region defined by at least one fluid-retaining surface, a field-responsive fluid situated in the fluid region, and a field generator for generating a magnetic or electric field across the fluid region. The fluid region is traversable by the at least one molecule. In response to a magnitude of the magnetic or electric field across the fluid region exceeding a threshold magnitude, a viscosity of the field-responsive fluid is greater than the first viscosity.

Devices, systems, and methods of using smart fluids to control molecule speeds

A system for controlling a translocation speed of a molecule through a nanopore may include a fluid chamber containing a solution with a magnetic susceptibility that is different from the magnetic susceptibility of the molecule, a nanopore situated in the fluid chamber, and at least one magnetic component configured to create a magnetic field gradient within the solution to control the translocation speed of a molecule through the nanopore. A system for controlling a translocation speed of a molecule through a nanopore may include a nanopore at least one magnetic component situated to create a magnetic field that causes the molecule to experience a rotational torque as it passes through the nanopore.

Magnetic control of molecule translocation speed through a nanopore

A device includes arrays of Non-Volatile Memory (NVM) cells. Reference sequences representing portions of a genome are stored in respective groups of NVM cells. Exact matching phase substring sequences representing portions of at least one sample read are loaded into groups of NVM cells. One or more groups of NVM cells are identified where the stored reference sequence matches the loaded exact matching phase substring sequence using the arrays at Content Addressable Memories (CAMs). Approximate matching phase substring sequences are loaded into groups of NVM cells. One or more groups of NVM cells are identified where the stored reference sequence approximately matches the loaded approximate matching phase substring sequence using the arrays as Ternary CAMs (TCAMs). At least one of the reference sequence and the approximate matching phase substring sequence for each group of NVM cells includes at least one wildcard value when the arrays are used as TCAMs.

Devices and methods for genome sequencing

A device for locating a sample read with respect to a reference genome includes a plurality of groups of cells. Each group of cells stores a reference sequence representing reference bases from the reference genome corresponding to an order of cells in the respective group of cells. Each group of cells further stores a current substring sequence representing sample bases from the sample read corresponding to the order of the cells in the respective group of cells. Each group of cells stores the same current substring sequence and a reference sequence representing a portion of the reference genome that partially overlaps at least one other portion of the reference genome represented by one or more other reference sequences stored in one or more other groups of cells. Groups of cells are identified among the plurality of groups of cells where the stored reference sequence matches the current substring sequence.

Devices and methods for locating a sample read in a reference genome

Methods and systems for processing a plurality of sample reads for genome sequencing include, for each sample read of the plurality of sample reads, comparing substring sequences from the sample read to reference sequences representing different portions of a reference genome. One or more reference sequences are identified that match one or more of the compared substring sequences, and a probabilistic location within the reference genome is determined for the sample read based on the one or more identified reference sequences. The plurality of sample reads is sorted into a plurality of sample groups based on the determined probabilistic locations of the respective sample reads.

Reference-guided genome sequencing

Disclosed herein are devices, systems, and methods for controlling a translocation speed of a molecule through a nanopore. In some embodiments, a speed-control device comprises at least one fluid-retaining surface, a fluid region, a field-responsive fluid coupled to the fluid-retaining surface and situated in the fluid region. In some embodiments, a system comprises the nanopore, the speed-control device, and a field generator for generating a magnetic or electric field across the fluid region. The viscosity of the field-responsive fluid is dependent on a magnitude of the magnetic or electric field across the fluid region and can be controlled by changing a magnitude of the magnetic or electric field across the fluid region.

Devices, systems, and methods of using smart fluids to control translocation speed through a nanopore

A system includes at least one waveguide with optical interaction portions that represent a sequence of reference symbols based on the order of the optical interaction portions in the at least one waveguide. At least one light source sends photons of one or more predetermined wavelengths into the at least one waveguide representing a string of query symbols. A detector detects photons received from the at least one waveguide that result from optical interactions between photons sent into the at least one waveguide and one or more corresponding optical interaction portions with an interaction between photons and an optical interaction portion indicating a match between a query symbol and a reference symbol. An analyzer determines one or more respective relative locations of the one or more corresponding optical interaction portions indicating one or more relative locations of the string of query symbols in the reference sequence.

Optical systems and methods for locating query symbols in a reference sequence

Methods and systems for processing a plurality of sample reads for genome sequencing include, for each sample read of the plurality of sample reads, comparing substring sequences from the sample read to reference sequences representing different portions of a reference genome. One or more reference sequences are identified that match one or more of the compared substring sequences, and a probabilistic location within the reference genome is determined for the sample read based on the one or more identified reference sequences. The reference genome is partitioned for reference-aligned genome sequencing based on the determined probabilistic locations of the respective sample reads.

Technology for operating cross-bar arrays is disclosed herein. The memory cells may each have a reversible resistivity element and a steering element comprising a diode. The cross-bar array may be operated in read mode and a bipolar programming mode. Selected memory cells may be sensed by operating the steering elements such that sense currents pass through the diodes and any sneak currents are blocked by the diodes. During bipolar programming of selected memory cells, the steering element of the selected memory cells allows current to flow in either direction through the steering element to permit bipolar programming. In some aspects, the steering element has a switch in parallel with the diode. The switches may be opened when sensing selected memory cells to pass sense currents and block sneak currents with the diodes. The switches may be closed during bipolar programming of the selected memory cells to allow bi-directional current flow.

Growing community of inventors

San Jose, CA, United States of America

Justin Kinney