Five Prime Therapeutics, Inc.

Justin G P Wong

Lewis T Williams

Kevin Hestir

Ernestine A Lee

Stephen Kohl Doberstein

Shannon Marshall

Elizabeth Bosch

Haishan Lin

Cindy Leo

Ge Wu

Aileen Zhou

Min Mei Huang

Amy L Tsui Collins

Keting Chu

Thomas Linnemann

Robert Forgan Halenbeck

Dirk Behrens

Steven Doberstein

Thomas Five Prime Therapeutics Inc Linnemann

Disclosed is a newly identified secreted molecule, identified herein as 'monocyte, granulocyte, and dendritic cell colony stimulating factor' (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.

Compositions and methods of use for MGD-CSF in disease treatment

Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.

Antibodies to stromal cell-derived factor-1 polypeptides

Stromal cell-derived factor-1 polypeptides, polynucleotides, modulators thereof and methods of use

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San Francisco, CA, United States of America

Justin G P Wong