Princeton University

Memorial Sloan Kettering Cancer Center

Agilent Technologies, Inc.

Justin Cross

Joshua D Rabinowitz

Craig B Thompson

Jurre Kamphorst

Craig Thompson

Joshua Rabinowitz

Steven Michael Fischer

Methods and compositions for treating Ras-related cancers are provided that involve targeting lipid scavenging. Methods and compositions for identifying and/or characterizing more or less responsive cancers are also provided.

Lipid scavenging in Ras cancers

Provided herein, among other things, is a method of ionizing a first stream of liquid by an electrospray ion source having a nebulizer, wherein the first stream of liquid may comprise an analyte. In some embodiments, the method may comprise: a) providing the first stream of liquid to the nebulizer; b) adding a second stream of liquid to the first stream of liquid, wherein the second stream of liquid comprises a co-solvent that has a relatively high boiling point and an enhancement solvent that a relatively high boiling; and c) nebulizing and ionizing the resulting liquid.

Method for enhancing electrospray

Growing community of inventors

New York, NY, United States of America

Justin Cross