Other

Jury Fedorovich Maichuk

Anatoly B Davydov

Gennady L Khromov

Alexei Nikolaevich Grinev

Grigory N Pershin

Nadezhda Sergeevna Bogdanova

Irina Sergeevna Nikolaeva

Maxim Yakovlevich Kraft

Inna Fedorovna Tishina

Galina Yakovlevna Uretskaya

Teshabai Nazarovich Avazov

Inna Fedorovna Tischina

Roza Isaakovna Abramishvili

Svetlana Jurievna Anikina

A medicinal preparation for treatment of viral-etiology diseases contains the bisulphite compound of 2-fluorenonyl-glyoxal in combination with a pharmaceutical vehicle or unctuous base. A method of producing the bisulphite compound of 2-fluorenonyl-glyoxal, viz, the active principle of said medicinal preparation, consists in that fluorene is acylated by dichloroacetyl chloride in the presence of aluminum chloride and phosphoryl chloride in an organic solvent, the resultant 2-.omega.-dichloroacetylfluorene is oxidized by the salts of chromic acid in an acetic-acid medium at 50.degree.-90.degree. C into 2-.omega.-dichloroacetylfluorenone which is made to interact with morpholine at 50.degree.-98.degree. C to form 2-.omega.-dimorpholinoacetylflourenone, or otherwise, fluorenone is acylated by acetic anhydride in an organic solvent in the presence of aluminum chloride, the resultant 2-acetylfluorene is oxidized by chromic acid or by the salts thereof in an acetic acid medium at 50.degree.-90.degree. C to obtain 2-acetylfluorenone which is brominated in an organic solvent at 60.degree.-110.degree. C, the resultant 2-.omega.-dibromoacetylfluorenone is reacted with morpholine at 50.degree.-98.degree. C to form 2-.omega.-dimorpholinoacetylfluorenone the latter is hydrolyzed by dilute mineral acids at 20.degree.-100.degree. C into 2-fluorenonyl-glyoxal hydrate which is then made to react with sodium bisulphite in an aqueous-alcohol medium at 60.degree.-80.degree. C to isolate the final product.

Medicinal preparation for treatment of viral-etiology diseases

A base for ophthalmological medicinal preparations consists of a homopolymer of an amide of acrylic acid having a molecular weight from 30,000 to 1,000,000, and/or a copolymer of an amide of acrylic acid with unsaturated compounds, the molecular weight of the copolymer being from 20,000 to 500,000, and containing from 10 to 90 per cent acrylamide links. The ophthalmological medicinal film is an oblong plate, 6-9 mm long, 3-5 mm wide and 0.2-0.6 mm thick, of the homopolymer and/or copolymer acrylamide links from 10 to 90 per cent, and an active medicinal ingredient, viz., 3-ethyl-4(1-methyl-5-imidazolyl)-tetrahydrofuran-2-one or atropine, or 3-methoxy-6-sulphanilan idopyridazine, or .beta.-dimethylamino-ethyl-p-butylaminobenzoate, or neamine, or 5-iodo-2-desoxyuridine. The ophthalmological medicinal film is used for treatment of glaucoma of various forms, thrombosis of the central vein of the retina, atrophy of the optic nerve, for dilating the pupil and paralysis of accommodation in treatment of keratitis, iritis, iridocyclitis, ulcers of the cornea, trachoma, herpetic keratitis, uveitis and adenoviral infections, in extraction of foreign objects from the eye, and in various interventions in the organ of vision.

Base for ophthalmological medicinal preparation on opthalmological

A base for ophthalmological medicinal preparations consists of a homopolymer of an amide of acrylic acid having a molecular weight from 30,000 to 1,000,000, and/or a copolymer of an amide of acrylic acid with unsaturated compounds, the molecular weight of the copolymer being from 20,000 to 500,000, and containing from 10 to 90 percent acrylamide links. The ophthalmological medicinal film is an oblong plate, 6-9 mm long, 3 - 5 mm wide and 0.2 - 0.6 mm thick, of the hompolymer and/or copolymer and an active medicinal ingredient, viz., 3-ethyl-4(1-methyl-5-imidazolyl)-tetrahydrofuran-2-one or atropine, or 3-methoxy-6-sulfanilam idopyridazine, or .beta.-dimethylamino-ethyl-p-butylaminobenzoate, or neamine, or 5-iodo-2-desoxyuridine. The ophthalmological medicinal film is used for treatment of glaucoma of various forms, thrombosis of the central vein of the retina, atrophy of the optic nerve, for dilating the pupil and paralysis of accommodation in treatment of keratitis, iritis, iridocyclitis, ulcers of the cornea, trachoma, herpetic keratitis, uveitis and adenoviral infections, in extraction of foreign objects from the eye, and in various interventions in the organ of vision.

Base for ophthalmological medicinal preparations and on ophthalmological

Growing community of inventors

Moscow, Russia

Jury Fedorovich Maichuk