Hoffmann-la Roche Inc.

Jurgen Wichmann

Geo Adam

Stephan Rover

Sabine Kolczewski

Andrea Cesura

Francedillaois Jenck

Thomas Johannes Woltering

Guido Galley

Heinz Stadler

Vincent Mutel

Michael Bos

Ulrich Widmer

Frank Dautzenberg

Philippe Nicolas Huguenin-Virchaux

Frederick Monsma, Jr

Caido Galley

The present invention relates to compounds of the formula ##STR1## wherein X is --O-- or --CH.sub.2 --;

Piperidine derivatives

The invention relates to compounds of the general formula ##STR1## wherein R.sup.1 is C.sub.6-12 -cycloalkyl, optionally substituted by lower alkyl or C(O)O lower alkyl, indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; acenaphthen-1-yl; bicyclo[3.3.1]non-9-yl, octahydro-inden-2-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl, decahydro-azulen-2-yl; bicyclo[6.2.0]dec-9-yl; decahydro-naphthalen-1-yl, decahydro-naphthalen-2-yl; tetrahydro-naphthalen-1-yl, tetrahydro-naphthalen-2-yl or 2-oxo-1,2-diphenyl-ethyl;

Diaza-spiro[3,5] nonane derivatives

The present invention relates to compounds of the general formula wherein

Spiro[piperidine-4,1'-pyrrolo [3,4-C] pyrrole]derivatives

The present invention relates to compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each independently hydrogen, lower alkyl, lower alkoxy or halogen;

1,3,8-triazaspiro[4,5]decan-4-one derivatives

The compounds of the formula ##STR1## wherein R signifies halogen or lower alkyl;

Heterocyclic vinyl ethers

The present invention relates to compounds of formula I and pharmaceutically acceptable acid addition salts thereof.

1,3,8,-triaza spiro (4,5)decan-4-on derivatives

This invention relates to (2S,2'R,3'R)-2-(2,3-dicarboxyl-cyclopropyl)-glycine of formula ##STR1## wherein R.sub.2 is hydrogen or tritium and to a process for the preparation thereof. The described compounds can be used as a pharmacological tool to study the function of group II mGluR (metabotropic glutamate receptor).

(2S,2'R,3'R)-2-(2,3-dicarboxyl-cyclopropyl)-glycine (DCG-1/4) and .sup.3

The invention is concerned with compounds of the general formula ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, phenyl or benzyl,

Phenyl-substituted 5H-thiazolo�3,2-A!pyrimidine derivative glutamate

The invention is concerned with the use of compounds of the general formula ##STR1## wherein R.sup.1 -R.sup.4 signify hydrogen, halogen, lower-alkyl, lower-alkoxy, aryl, benzyloxy, lower-alkoxy-lower-alkyl, lower-alkyl-sulphanyl, lower-alkyl-sulphanyl-lower-alkyl or R.sup.1 and R.sup.2 together signify the group --O--(CH.sub.2).sub.2 -- or --(CH.sub.2).sub.2 --O-- and

Method of treating diseases of the CNS

The invention relates to tricyclic pyrrole derivatives useful as 5-HT selective agents of the formula ##STR1## wherein R.sup.1 to R.sup.4 are, independently, hydrogen, halogen, lower alkyl, phenyl, cycloalkyl or lower alkoxy and R.sup.2 additionally is lower alkoxycarbonyl, acyloxy or mesyloxy;

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Steinen, Germany

Jurgen Wichmann