Veb Arzneimittelwerk Dresden

Veb Fahlberg-list Chemische Und Pharmazeutische Fabriken

Jurgen Slapke

Tankred Schewe

Horst Lyr

Dieter Zanke

Thomas Strumpf

Lothar Lucke

Walter Furst

Samuel M Rapoport

Gunter Voigt

Hartmut Kuhn

Gerhard Fries

Renate Grupe

Reinhard Neubert

Improved bioavailability, particularly when the drug is administered orally, of the active ingredient 2-hydroxy-5-methyllaurophenoxime (HMLO) of a pharmaceutical preparation is achieved by improving the absorption of the active ingredient HMLO significantly by including bile acids in the preparation. As bile acids, it is possible to use, for example, desoxychloic acid or dehydrocholic acid or a mixture of the two in the form of their salts.

Composition and methods for providing optimum bioavailability of the

Hydroxamic acids, pharmaceutical preparations containing the same, new .omega.(2'-naphthoxy)-alkylhydroxamic acids as well as a process for their production are disclosed. The new compounds display antiasthmatic and further pharmacologically valuable characteristics. They are prepared by reacting the corresponding carboxylic acid ester or amide with hydroxylamine or its salt under the described conditions into compounds of Formula I,

Hydroxamic acid and pharmaceutical preparations containing the same

Growing community of inventors

Schwanebeck, Germany

Jurgen Slapke