Xeltis Ag

Jurgen Sander Miedema

Martijn Antonius Johannes Cox

Methods and the resulting structures, like valve devices (e.g. heart or vessel) are provided made by electrospinning single shapes on mandrels with complex surface shapes. These single shapes are then shaped into valves with a plurality of leaflets. Three levels of complexity of shapes are described: 1) conical shapes, 2) a combination of conical and cylindrical shapes, and 3) a conical and/or cylindrical shape which has further complexity by one or more three-dimensional shapes. Heart valves resulting from these complex electrospun shaped mandrels have better mobility dynamics compared to heart valves electrospun on solely cylindrical mandrels.

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Mels, Switzerland

Jurgen Sander Miedema