Behringwerke Aktiengesellschaft

Aventis Behring Gmbh

Behring Diagnostics Gmbh

Centeon Pharma Gmbh

Jurgen Romisch

Norbert Heimburger

Werner Stuber

Michael Kraus

Klaus Habenstein

Bernhard Auerbach

Harald Stauss

Hermann Pelzer

Hartmut Lobermann

Jurgen Lindner

Eckhard Schuler

A process for determining glycosaminoglycans in antithrombin III (ATIII)-containing solutions by increasing the ionic strength of the AT III-containing solution until the interaction between AT III and glycosaminoglycans is prevented, removing the AT III which has been released from the glycosaminoglycans from the solution, and desalting and determining the glycosaminoglycan which has remained in the solution.

Process for quantifying glycosaminoglycans in antithrombin

The invention relates to a method for the quantification of coagulation factor VIIa (F VIIa) in FVIIa- or FVII/FVIIa-containing solutions by means of selective binding to immobilized soluble thromboplastin.

Method for the quantification of activated coagulation factor VII (FVIIa)

The invention relates to a sampling kit for obtaining, in a rapid and gentle manner, a defined volume of lacrimal fluid for the purpose of reproducibly determining components of the lacrimal fluid.

Method for reproducibly determining the components of lacrimal fluid

A method for stabilizing the functional activity of annexins in a biological fluid sample is provided.

Method for stabilizing annexins

The invention relates to a method for the determination of antibodies against lipocortins (annexins) in a body fluid of a species, using proteins from the lipocortin family bound to a solid phase and using a labeled bioaffinity binding partner which is directed against single classes or a plurality of classes of immunoglobulins of this species.

Method for the determination of antibodies against lipocortins

A process for removing toxins from solutions of proteins, in which an aqueous solution of a protein which contains a buffer substance, a chelating agent and a detergent is subjected to an ion exchange chromatography, is described.

Process for removing toxins from protein solutions

The invention relates to a method for the purification of the a subunit of factor XIII by affinity chromatography, to a therapeutic composition containing the latter, and to the use of the therapeutic composition. Factor XIII has hitherto been purified either by methods which are technically very elaborate or else by use of toxic affinity chromatography materials. The invention has the aim of providing an improved method for the purification of the a subunit of factor XIII. Factor XIII is obtained according to the invention by a method in which the a subunit of factor XIII is reversibly bound to a matrix suitable for disulfide exchange reactions and is removed from the matrix by reaction with a reducing agent. The method according to the invention makes it possible to provide the biologically active a subunit of factor XIII in high purity.

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Marburg, Germany

Jurgen Romisch