Merck Patent Gesellschaft MIT Beschrankter Haftung

Jurgen Maisenbacher

Reinhard Lissner

Manfred Baumgarth

Dieter Orth

Hans-Eckart Radunz

Joachim Gante

Werner Mehrhof

Gotz Leopold

Compounds of formula ##STR1## their mirror images and racemic mixtures, and the physiologically acceptable salts thereof,

New prostaglandin-like diketals

Compounds of the Formula ##STR1## and the physiologically acceptable salts thereof, wherein R.sup.1 and R.sub.2 each is hydrogen or benzyl; R.sup.3 is alkyl of 5-10 C-atoms or 2-hydroxyalkyl of 5-10 C-atoms; R.sup.4 is hydrogen, methyl or ethyl; R.sup.5 is alkyl of 5-10 C-atoms or --C.sub.n H.sub.2n COOR.sup.6 ; R.sup.6 is hydrogen or alkyl of 1-4 C-atoms; and n is 0, 4, 5 or 6 are effective for inhibiting adhesion and/or agglomeration of thrombocytes.

Cyclopentan-1-amines

1,4-Oxathianes of the formula ##STR1## and the physiologically-acceptable salts thereof wherein R.sup.1 is H or alkyl with 1-4 C-atoms; R.sup.2 is H or alkyl with 1-4 C-atoms; R.sup.3 is H, alkyl with 1-8 C-atoms, phenyl or phenyl substituted by F, Cl, Br, OH, OCH.sub.3, CF.sub.3 or NO.sub.2 ; R.sup.4 is H or CH.sub.3 ; B is a single bond, --CH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --CH.sub.2 O--; and a wavy line (  ) indicates that these bonds can be in the .alpha.- or .beta.- positions possess thrombocyte inhibition properties.

1,4-Oxathianes

2-(4,5-BIS-P-CHLOROPHENYLOXAZOL-2-YL-MERCAPTO)-PROPIONIC ACID AND ITS PHYSIOLOGICALLY ACCEPTABLE SALTS IS USEFUL FOR SUPPRESSING AGGREGATION OF THROMBOCYTES, PARTICULARLY WHEN ADMINISTERED IN COMBINATION WITH ASPIRIN.

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Darmstadt, Germany

Jurgen Maisenbacher