Boehringer Mannheim Gmbh

Jurgen Horn

Hans-Georg Batz

Josef Maier

Gunter Weimann

Klaus Stellner

Michael Nelboeck-Hochstetter

Winfried Albert

Dieter Jaworek

Michael Nelbock-Hochstetter

New hydroxy-succinimide ester compounds of the formula ##STR1## wherein X is selected from a carboxy-succinimide ester group and radicals of the general formulae: ##STR2## A is -O-CH.sub.2 -CH.sub.2 when n is 2 and X is a succinimide ester group but otherwise is a single bond;

Hydroxy-succinimide ester compounds

Biologically active protein compositions comprising protein or a protein substrate bound onto a polyamide of the general formula: ##STR1## in which R and R.sub.1, which may be the same or different, are polyamide residues bound onto the amido group,

Polyamide-fixed biologically active protein

New hydroxy-succinimide ester compounds of the formula ##STR1## wherein X is selected from a carboxy-succinimide ester group and radicals of the general formulae: ##STR2## A is --O--CH.sub.2 --CH.sub.2 when n is 2 and X is a succinimide ester group but otherwise is a single bond;

Biologically active proteins are immobilized onto a carrier by reacting a compound containing at least two secondary amino groups at a temperature of from -80.degree. to +50.degree. C with a chlorination agent with the conversion of the secondary amino groups into iminochloride groups of the formula ##STR1## in which R and R.sub.1, which can be the same or different, are aliphatic, aromatic or aliphatic-aromatic radicals, and reacting the carrier material product thus obtained

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Tutzing-Garatshausen, Germany

Jurgen Horn