Schering Aktiengesellschaft

Jurgen Hilmann

Peter Fuchs

Ned S Rasor

Thomas Fritzsch

Joachim Siegert

Ingfried Zimmermann

Lothar Lange

Microparticles which are less than 12 .mu.m in size and are formed of or comprise a solid lipophilic group-containing compound having an HLB value less than about 20 produce a long lived ultrasonically echogenic entity in aqueous liquid and are useful as left heart ultrasonic contrast image enhancing agents. Contrast media for ultrasonic diagnostics comprising a liquid vehicle containing (a) suspended therein microparticles of a mixture of at least one (C.sub.8 -C.sub.20)-fatty acid and at least one solid that is not a surfactant and (b) microbubbles, are especially effective upon ultrasonic imaging after intravenous administration, for the contrasting of both the right heart and left heart, of the myocardium, as well as other organs, such as liver, spleen, and kidneys.

Ultrasonic contrast medium comprising gas bubbles and solid lipophilic

Pharmaceutical composition unit dosage forms adapted for enteral or topical administration are described, comprising a safe and effective amount of a pharmaceutically active medicament compound dissolved or uniformly dispersed in a flexible, water-soluble film carrier therefor. Admixtures of medicament and carrier are drawn into a film, which can be cut to desired unit dosage content.

Medicament carriers in the form of film having active substance

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Berlin, Germany

Jurgen Hilmann