Los Alamos National Security, LLC

University of California

Triad National Security, LLC

Other

Jurgen G Schmidt

Robert F Williams

Louis A Silks

Clifford J Unkefer

Basil I Swanson

Marc A Alvarez

Xuedong Song

Ryszard Michalczyk

Pulak Nath

Michelle A Espy

Robert Henry Kraus, Jr

David Bryan Kimball

Per Erik Magnelind

Rudolfo A Martinez

Jacob Luther Yoder

Robert W Atcher

Derrick C Kaseman

Scarlett Widgeon Paisner

Algis V Urbaitis

Michael Timothy Janicke

Douglas E Berning

Rodolfo Antonio Martinez

John Cameron Gordon

Robert David Gilbertson

Charlie E Strauss

John R Barr

Andrew M Dattelbaum

Pavel A Dub

Suzanne R Kalb

Aaron S Anderson

Anne E Boyer

Yury Minko

Tammie Renee Nelson

Shirley Jean Schmidt

Paul William Peterson

Hercules Moura

Adrian R Woolfitt

A nuclear magnetic resonance (NMR) system is configured to detect combinatorial signatures stemming from homonuclear and heteronuclear J-couplings. The system comprises a pre-polarization system, a detector, and NMR electronics, wherein the detector includes an NMR magnet with a magnetic field of strength between 300 mT and 10 &#x3bc;T.

Methods and systems for J-coupled nuclear magnetic resonance

A nuclear magnetic resonance (NMR) system is configured to detect chemical threat material. The system comprises a magnet configured to generate a magnetic field of about 300 millitesla or less; and a probe configured to detect nuclear relaxation of at least two nuclei selected from the group consisting ofH,F,P andN, and detect the spin density of nuclei selected from the group consisting ofH,F,P andN, following excitation.

Methods and systems for low to ultra-low magnetic field nuclear magnetic resonance for detecting chemical nerve agents

The present disclosure provides improved methods for controlled cyclization of peptoid dimers to form N,N'-2,5-diketopiperazines (N,N&#x2032;-2,5-DKPs) with significant selectivity. In at least some examples, selectivity is based on a serendipitous conglomeration of slow exchange of amide rotamers, steric repulsion from the degree of &#x3b1;-substitution, and the geometric bulk of an amine nucleophile. By varying reaction conditions, the selectivity of the reaction and formation of a particular N,N&#x2032;-2,5-DKP can be switched. The cyclization works in the presence of a variety of protection groups and diverse functionalities. The teachings herein provide techniques for synthesizing N,N&#x2032;-2,5-DKPs that can be readily docked with drug candidates for shuttling across the blood brain barrier. This method provides a facile way to produce substituted DKPs containing groups ready for post-modification to include docking drug candidates.

Controlled cyclization of peptoids to form chiral diketopiperazines

Disclosed herein are embodiments of chiral and achiral macrocyclic polydentate ligands and methods of preparing the same. Disclosed herein are also embodiments of metal coordination complexes derived from these macrocyclic polydentate ligands and methods of preparing the same. The metal coordination complexes described herein, can be used for a variety of catalytic reactions, including hydrogenation and transfer hydrogenation of unsaturated organic compounds, dehydrogenation of alcohols and boranes, an asymmetric Michael-type addition reaction, or an aerobic oxidative kinetic resolution of an organic compound, dehydrogenative couplings and other catalytic transformations.

Macrocyclic ligands and their complexes for bifunctional molecular catalysis

The present invention provides a composite material including a substrate having an oxide surface, and, a continuous monolayer on the oxide surface, the monolayer including a silicon atom from a trifunctional alkyl/alkenyl/alkynyl silane group that attaches to the oxide surface, an alkyl/alkenyl/alkynyl portion of at least three carbon atoms, a polyalkylene glycol spacer group, and either a reactive site (e.g., a recognition ligand) or a site resistant to non-specific binding (e.g., a methoxy or the like) at the terminus of each modified SAM. The present invention further provides a sensor element, a sensor array and a method of sensing, each employing the composite material. Patterning is also provided together with backfilling to minimize non-specific binding.

Robust, self-assembled, biocompatible films

Compounds having stable isotopesC and/orH were synthesized from precursor compositions having solid phase supports or affinity tags.

Isotopically labeled compositions and method

The present invention is directed to a method for detecting the presence of clostridial neurotoxins in a sample by mixing a sample with a peptide that can serve as a substrate for proteolytic activity of a clostridial neurotoxin; and measuring for proteolytic activity of a clostridial neurotoxin by a mass spectroscopy technique. In one embodiment, the peptide can have an affinity tag attached at two or more sites.

Mass spectrometry-based methods for detection and differentiation of botulinum neurotoxins

A process of preparing gold-coated magnetic nanoparticles is disclosed and includes forming a suspension of magnetic nanoparticles within a suitable liquid, adding an amount of a reducible gold compound and a reducing agent to the suspension, and, maintaining the suspension for time sufficient to form gold-coated magnetic nanoparticles.

Gold-coated nanoparticles for use in biotechnology applications

A sensor for the detection of tetrameric multivalent neuraminidase within a sample is disclosed, where a positive detection indicates the presence of a target virus within the sample. Also disclosed is a trifunctional composition of matter including a trifunctional linker moiety with groups bonded thereto including (a) an alkyl chain adapted for attachment to a substrate, (b) a fluorescent moiety capable of generating a fluorescent signal, and (c) a recognition moiety having a spacer group of a defined length thereon, the recognition moiety capable of binding with tetrameric multivalent neuraminidase.

Influenza sensor

A novel nucleoside analog is disclosed which comprises a piperazine ring in the place of the ring ribose or deoxyribose sugar. Monomers utilizing a broad variety of nucleobases are disclosed, as well as oligomers comprising the monomers disclosed herein linked by a variety of linkages, including amide, phosphonamide, and sulfonamide linkages. A method of synthesizing the nucleoside analogs is also disclosed.

Piperazine-based nucleic acid analogs

Synthesis of &lsqb;2H1, 13C&rsqb;, &lsqb;2H2, 13C&rsqb; and &lsqb;2H3, 13C&rsqb;methyl aryl sulfones and sulfoxides

Growing community of inventors

Los Alamos, NM, United States of America

Jurgen G Schmidt