Imtm Gmbh

Jürgen Faust

Siegfried Ansorge

Klaus Neubert

Uwe Lendeckel

Dirk Reinhold

Robert Vetter

Harald Gollnick

Michael Täger

Ute Bank

Irene Reichstein

Petra Fuchs

Christos Zouboulis

Bianca Senns

Compounds of the general formulae (1) and (2)A-B-D-B'-A&#x2032;&#x2003;&#x2003;(1)andA-B-D-E&#x2003;&#x2003;(2)in which 

Dual-use peptidase inhibitors as prodrugs for a therapy of inflammatory and other diseases

The invention relates to a process for the-inhibition of the DNA synthesis necessary for the proliferation of human sebaceous cells (sebocytes) by the isolated or joint effect of inhibitors of alanyl aminopeptidase (APN) and dipetidyl peptidase IV (DP IV) expressed by these cells. The DNA synthesis (proliferation) of human sebaceous cells is inhibited by the administration of the inhibitors of APN and/or of DP IV depending on the dose. Our invention shows that, for a therapy and for a prevention of dermatological diseases with sebaceous hyperproliferation and modified conditions of differentiation, the application of inhibitors of the above-mentioned enzymes and of corresponding pharmaceutical preparations and dosage forms thereof is suitable.

Use of enzyme inhibitors of aminopeptidase N and/or dipeptidylpeptidase IV

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Halle, Germany

Jürgen Faust