A. Nattermann & Cie Gmbh

Nattermann & Cie Gmbh

A. Natternabb & Cie Gmbh

Jurgen Biedermann

Gerrit Prop

Erich Graf

Michel Evers

Hans Betzing

Sigurd Leyck

Gerd Hilboll

Ille-Stephanie Doppelfeld

Harald O Borbe

Rolf Terlinden

Volker Neuser

Eugen Etschenberg

Johannes Winkelmann

Armin Wendel

Carsten Materne

Hartmut Fischer

Hugo Friehe

Wolfgang Scheef

Anti-inflammatory benzylselanobenzamides made from anilines and benzylamines have the formula I ##STR1## are disclosed wherein R is hydrogen, methyl or ethyl;

Anti-inflammatory benzylselenobenzamides made from anilines and

Benzylselenobenzamides of formula I ##STR1## with inflammation-inhibiting characteristics and used in pharmaceutical preparations.

Antiinflammatory benzylselenobenzamides from aminopyridines and

The invention relates to a new process for the treatment of hypertension and thromboembolic diseases in humans by simultaneous administration of (.+-.)- or (-)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene hydrochloride on the one side, and 4,5-dihydro-6-[4-(1-imidazolyl)-phenyl]-5-methyl-3(2H)-pyridazinone or 4,5-dihydro-6-[4-(1-imidazolyl)-thien-2-yl]-5-methyl-3(2H)-pyridazinone, on the other side, as the active substances.

Process for reducing reflex tachycardia in the treatment of hypertension

This invention relates to processes for producing the (-)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene and to pharmaceutically acceptable acid addition salts thereof and the method for lowering the blood pressure in human beings suffering from increased blood pressure, using these compounds.

Process for producing

The invention relates to the new optically active dipeptide D-2-phenylglycyl-D-2-phenylglycine and its pharmacologically acceptable salts or acid addition salts and the use thereof as tissue dissolving and histolytic agent.

Optically active dipeptides and the use thereof as tissue dissolving and

This invention relates to (+)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene and to pharmaceutically acceptable acid addition salts thereof and the method for the treatment of human beings suffering from nervous disarrangements, in particular migraine, using these compounds.

(+)-2-[1-(2,6-Dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene and the

2-Oxo-1-pyrrolidinylalkylcarboxylic acid amides of formula I ##STR1## in which R represents a hydrogen atom or hydroxy group, R.sub.1 represents a hydrogen atom or a methyl group and R.sub.2 represents a substituted or unsubstituted pyridyl group or a substituted phenyl group, the substitution being by from 1 to 3 substituents, which may be the same or different selected from halogen atoms, trifluoromethyl, nitro and acetyl groups, straight or branched-chain alkyl groups having 1-4 carbon atoms, alkoxy groups having 1-4 carbon atoms, straight or branched-chain alkylmercapto groups having 1-7 carbon atoms, substituted alkylmercapto groups of the general formula II ##STR2## in which n represents 1 or 2, R.sub.3 is a hydrogen atom or a methyl group and R.sub.4 is a hydroxy group or an amino group of the general formula V ##STR3## in which R.sub.8 represents a hydrogen atom or methyl group and R.sub.9 represents a methyl group or substituted or unsubstituted benzyl group, or R.sub.8 and R.sub.9 together with the nitrogen atom shown in formula V, form a substituted pyrrolidine ring; sulphonyl groups of the general formula III

Pyrrolidinylalkylcarboxylic acid amide derivatives, their preparation

The invention provides N-propionylsarcosineanilides of the formula: ##STR1## wherein n is an integer of 1 to about 3 and the substituent A which can be the same or different when n is greater than 1 is selected from the group consisting of trifluoromethyl; halogen; nitro; acetyl; a straight-chain or branched alkyl group having 1 to 4 carbon atoms; a straight-chain or branched alkoxy group having 1 to 4 carbon atoms; a straight-chain or branched alkylmercapto group having 1 to 7 carbon atoms; a substituted alkylmercapto group of the formula: ##STR2## wherein n is an integer of 1 or 2, R.sub.1 can represent hydrogen and methyl, and R.sub.2 can represent hydroxyl, and an amino group of the formula:

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Pulheim-Stommeln, Germany

Jurgen Biedermann