Bioverativ Therapeutics Inc.

Biogen Idec Hemophilia Inc.

Biogen Hemophilia Inc.

Jurg Sommer

Haiyan Jiang

Glenn Pierce

Robert T Peters

Susan C Low

Jennifer A Dumont

Alvin Luk

Byron McKinney

Matt Ottmer

Karen Nugent

Lian Li

Alan J Bitonti

Xin Zhang

Buyue Yang

Alan J Bitoni

Byron Mckinney

The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.

Factor VIII chimeric and hybrid polypeptides, and methods of use thereof

The present invention provides methods of dosing Factor VIII or Factor IX chimeric and hybrid polypeptides. The present invention further provides high-sensitivity methods of quantifying an amount of activated FIX protein in a test sample.

Assays to monitor bleeding disorders

The present disclosure provides methods and compositions for diagnosing and treating subject having a bleeding disorder. The disclosed methods comprise contacting a sample, e.g., a blood or plasma sample obtained from the patient, with an activation mixture comprising an activated coagulation factor and a phospholipid mixture, wherein the activation mixture is dried onto a solid substrate. Also provided is a global hemostasis test based on the integration of clotting time (Ct) and pharmacokinetics data. The methods and compositions presented can be applied to point-of-care diagnostic systems.

Blood factor monitoring assay and uses thereof

The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.

Factor VIII-FC chimeric and hybrid polypeptides, and methods of use thereof

Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof

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Wayland, MA, United States of America

Jurg Sommer