Novo Nordisk A/s

Roche Diagnostics Operations, Inc.

Jure Piskur

Michi Egel-Mitani

Hans-Georg Ihlenfeldt

Brigitte Munch-Petersen

Leif Sondergaard

Aradhana Srivastava

A recombinantdeoxynucleoside kinase that remains stable during the synthesis of nucleoside monophosphate without the addition of stabilizing SH reagents or stabilizing proteins, and that accepts all four natural deoxynucleotides is provided. In addition, the invention concerns DNA sequences, vectors, transformed cells, a method for production of the recombinant kinase as well as its use for preparing nucleoside monophosphates.

Recombinant kinase from insect cells for the synthesis of nucleoside monophosphates

The invention describes industrial fermentation of a Saccharomyces yeast species for production of a heterologous product encoded by a plasmid or DNA contained in said Saccharomyces yeast species which method utilizes the substrate more efficiently and without fermentative metabolism resulting in formation of ethanol and other unwanted primary products of fermentative activity whereby high yields of the heterologous product are obtained. The Saccharomyces yeast species is preferably a Crabtree negative Saccharomyces species in particular

Method for the production of heterologous polypeptides in transformed yeast cells

Growing community of inventors

Copenhagen, Denmark

Jure Piskur