Nippon Shinyaku Company, Ltd.

Sugiyama, Makoto

Seki, Junzo

Okita, Atsuhiko

Junzo Seki

Hirofumi Yamamoto

Kazuko Hirabayashi

Yutaka Takahashi

Tadaaki Ohgi

Shuji Yamane

Kouichi Ishiyama

Kouichi Ushimaru

Shinji Matsuyama

Katsuhiro Sugihara

Makoto Sugiyama

Hiroshi Fukui

Satoru Sonoke

Atsuhiko Okita

Akira Saheki

Hirofumi Yoshikawa

Hideki Sasaki

Kazuko Greenpalace Kaikonoyashiro Hirabayashi

The present invention provides a chain-shortened polynucleotide wherein the proportion of a 2'-5&#x2032; phosphodiester bond is up to 3% based on the whole phosphodiester bonds or a salt thereof and a pharmaceutical composition containing the same, and a method for producing the same.

Chain-shortened polynucleotide and method for preparation thereof

The object of the present invention is to provide a novel medicinal agent useful in the treatment or the prevention of hepatitis. The present invention is, for example, a therapeutic or preventive agent for hepatitis characterized in that it comprises a complex of a drug carrier consisting essentially of 2-O-(2-diethylaminoethyl)-carbamoyl-1,3-O-dioleoylglycerol and a phospholipid with poly(I).poly(C).

Remedies for hepatitis

The present invention provides a chain-shortened polynucleotide wherein the proportion of a 2&prime;-5&prime; phosphodiester bond is up to 3% based on the whole phosphodiester bonds or a salt thereof and a pharmaceutical composition containing the same, and a method for producing the same.

A method for producing a composition including a nucleic-acid-containing complex is characterized in that two single strand nucleic acid polymers which can at least partly form double strands are separately mixed, in a single strand form, with a cationic carrier or with source materials for the cationic carrier before the cationic carrier is formed. The resulting mixture is then dispersed in water during the production process of the nucleic-acid-containing complex.

Process for producing composite preparation containing nucleic acid

Fat emulsions for inhalational administration

An O/W medical fat emulsion for oral administration, which is capable of increasing the bioavailability of a medicine or the blood level thereof. The emulsion is composed of fat emulsion particles containing an oil component, an emulsifier and a medicine as the indispensable constituents and dispersed in water, characterized in that the average diameter of the particles in the fat emulsion ranges from 5 to 50 nm. A freeze-dried preparation of the emulsion is also included in the invention.

Fat emulsion for oral administration

PGE.sub.1 -containing-freeze dried preparation and process for the

Method of producing emulsions and an emulsification apparatus

Dispersion preparation

A drug carrier useful for improved drug delivery upon administration comprising a fat or fatty emulsion as a core and a surface layer thereover wherein the core amounts to 30% to 65% and the surface layer amounts to 35% to 70%. The constituents of the core and surface layer are detailed together with the improved drug delivery obtained. The emulsion has a mean particle diameter less than 100 nm.

Drug carriers

Lyophilized fatty emulsions and a process for the production thereof

Stable homogeneous fatty emulsions containing amphotericin B are prepared. According to one embodiment, amphotericin B is decrystallized using an acid and ethanol and then homogeneously dispersed in a lipid, following which it is emulsified. According to a second embodiment, amphotericin B crystals are kneaded until their presence can no longer be confirmed and the decrystallized amphotericin B is thereafter uniformly dispersed in a lipid and, thereafter, emulsified.

Process for producing fat emulsion

Growing community of inventors

Ibaraki, Japan

Junzo Seki