Toyo Jozo Company, Ltd.

Toyo Jozo Kabushiki Kaisha

Junzo Mizoguchi

Naoki Muto

Tetsu Saito

Masaru Otani

Shuzo Satoi

Masami Akasaka

Akiko Kubota

Masami Ohya

Sakae Satoh

Takashi Onozawa

DNA having genetic information of a human plasma-type glutathione peroxidase h-p.multidot.GSHPx was identified and disclosed. The enzyme, h-p.multidot.GSHPx, is produced by the expression of said DNA genetic information by a transformant holding a vector into which said DNA is incorporated. The DNA and the transformant ensures efficient production of human plasma type h-p.multidot.GSHPx. The enzyme exhibits lipid peroxide extinction activity, and is considered to be useful for the treatment or the cure or the prevention of these diseases.

Plasma-type glutathione peroxidase gene and application of the same

DNA which encodes at least a polypeptide containing glutathione peroxidase activity and having an amino acid sequence from the N-terminal to the C-terminal of the formula: ##STR1## wherein * * * is selenocystein, is produced by culturing transformant host cells which possess extraneous DNA encoding a polypeptide with glutathione peroxidase activity in a medium containing selenium, and separating a thus-produced polypeptide with glutathione peroxidase activity from the cultured mass.

Glutathione peroxidase gene and process for production of the gene

An amino sugar compound represented by the general formula: ##STR1## (wherein m is an integer of 0 to 8, n is an integer of 1 to 8 and m+n is an integer of 1 to 8) has strong glycosidase inhibiting action and is produced by culturing an amino sugar compound producing microorganisms belonging to Streptomyces.

Amino sugar compound

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Shizuoka, Japan

Junzo Mizoguchi