Toray Industries, Inc.

Nippon Chemiphar Co., Ltd.

Yamasa Corporation

Junzo Kamei

Hiroshi Nagase

Kuniaki Kawamura

Toshiaki Tanaka

Koji Kawai

Toshiyasu Imai

Jun Utsumi

Takashi Endoh

Toichi Abiru

Kazuki Endo

Noriyuki Hirano

Takashi Endo

Akira Mizusuna

The present invention pertains to a medicament for preventing or treating cough, including, as an active ingredient, a compound having P2X4 receptor antagonistic action, a tautomer, stereoisomer, or pharmaceutically acceptable salt of the compound, or a hydrate or solvate thereof.

Medicament for treating cough

The present invention relates to an agent for the prophylaxis or treatment of diabetic neuropathy, which contains cytidine 5'-diphosphocholine (CDP-choline) as an active ingredient. The agent for the prophylaxis or treatment of diabetic neuropathy of the present invention is effective for neuropathy mainly caused by metabolic disturbance of carbohydrate and is also superior in safety. Neuropathy includes peripheral neuropathy and dysautonomia. CDP-choline is effective even by oral administration.

Pharmaceutical composition for diabetic neuropathy

Medicinal composition for diabetic neuropathy

Disclosed is an agent for improving learning and/or memory, which is useful for therapy of dementia accompanying disorder of memory due to a cerebrovascular disease, neurodegenerative disease such as Alzheimer's disease, endocrine disease, nutritional or metabolic disorder, infectious disease, drug addiction or the like. The agent for improving learning and/or memory according to the present invention comprises as an effective ingredient an isoquinoline derivative having a specific structure, such as (4aR, 12aR)-2-methyl-4a-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12a-octahydro-quinoline&lsqb;2,3-g&rsqb;isoquinoline or a pharmaceutically acceptable salt thereof.

Agent for improving learning or memory

Antitussives

This invention provides an antipruritc comprising an opiate &kgr; receptor agonist as an effective component, a new morphinan quaternary ammonium salt derivative and a new morphinan-N-oxide derivative which are useful in treating pruritus complicated with some diseases.

Antipruritic

This invention provides an antipruritic comprising an opiate &kgr; receptor agonist as an effective component, a new morphinan quaternary ammonium salt derivative and a new morphinan-N-oxide derivative which are useful in treating pruritus complicated with some diseases.

Antipruritic agent

Antitussive

Growing community of inventors

Yokohama, Japan

Junzo Kamei