Synta Pharmaceuticals Corporation

Madrigal Pharmaceuticals, Inc.

Junyi Zhang

Shoujun Chen

Jun Jiang

Yu Xie

Lijun Sun

Zhi-Qiang Xia

Weiwen Ying

Dinesh U Chimmanamada

Gary Bohnert

Genliang Lu

Nha Huu Vo

Teresa Kowalczyk-Przewloka

Zhiqiang Xia

Qinglin Che

Neera Jain

Zhi Qiang Xia

James Loch

Dharma Vutukuri

Sami Osman

Amit Kale

The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.

Targeted therapeutics

The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein Y, L, X, X, Z, R, R, and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

Pyridylphenyl compounds for inflammation and immune-related uses

The invention relates to compounds of structural formula (I) or (III): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein ring A, X, X, X, X, R, R, Y, Z, L, m and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses

The invention relates to compounds of structural formulas (I), (VII) and (XI): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein X, X, X, Y, Z, L, R, R, R, Rand n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

Compounds for inflammation and immune-related uses

This invention relates to certain biologically active chemical compounds, such as benzoimidazolyl-pyrazine derivatives of formula (I) or pharmaceutically acceptable salts thereof. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders. 

Substituted benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses

The invention relates to certain compounds including substituted pyridines, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

Compounds inclunding substituted pyridines for inflammation and immune-related uses

Biologically active chemical compounds, namely benzoimidazolyl-pyrazine derivatives and structurally related compounds, are disclosed herein. Such compounds include those represented by structural formula (II): and as described in further detail within. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

Growing community of inventors

Lowell, MA, United States of America

Junyi Zhang