Beijing Fswelcome Technology Development Co., Ltd.

Beijing Showby Pharmaceutical Co., Ltd.

Beijing Shuobai Pharmaceutical Co., Ltd.

Junyi Wang

Zejun Gao

Xiaoping Chen

Shouming Wen

Chunjing Wang

The invention provides a class of compounds represented by formula (I), having bifunctional active quaternary ammonium salt structure of a &#x3b2;-adrenoreceptor agonist and an M receptor antagonist, a pharmaceutically acceptable salt, solvate, and optical isomer thereof. A pharmaceutical composition comprising such a compound with quaternary ammonium salt structure, a method for preparing such a compound with quaternary ammonium salt structure and an intermediate thereof, and uses thereof in treating pulmonary disorders are also provided. The compounds of the invention have high selectivity to the M receptor subtype, and have less adverse reaction and lower toxic and side effects in the treatment of pulmonary diseases such as COPD and asthma. 

Class of bifunctional compounds with quanternary ammonium salt structure

The present invention discloses a class of quinine compounds and pharmaceutically acceptable salts, solvates, prodrugs or optical isomers thereof. Also disclosed in the present invention are that the above compounds have a selective antagonistic effect on the receptor subtypes of Mand M, but have no significant effect on Mreceptor subtype, and the above compounds are characterized by rapid action, long-lasting efficacy, and low toxic and side-effects when used to treat rhinitis, post-cold rhinitis, chronic trachitis, airway hyperresponsiveness, asthma, chronic obstructive pulmonary diseases, cough, urinary incontinence, frequent urination, unstable bladder syndrome, bladder spasms, bladder inflammation and gastrointestinal diseases such as irritable bowel syndrome, spastic colitis, as well as duodenal and gastric ulcers.

Quinine compounds, and optical isomers, preparation method and medical use thereof

Growing community of inventors

Beijing, China

Junyi Wang