Chemigen

Other

Huaxiashengsheng Pharmaceutical Beijing Co., Ltd.

Junyi Liu

Yansheng Du

Zhizhong Ma

Xinan Lv

Jirun Peng

Shouxin Zhou

Xiang Ao

Carbamate-substituted styryl sulfone compounds have a structure of general formula (I). The compounds not only has a significantly enhanced acetylcholinesterase inhibitory activity compared with carbamates as positive drugs, but also has a significantly enhanced therapeutic effect on Parkinson's disease compared with caffeic acid phenethyl ester compounds having similar structures.

Carbamate-substituted styryl sulfone compounds, preparation method and use thereof

Disclosed is the use of the compounds represented by formula (I) in the preparation of a medicament against tumor angiogenesis, wherein Rand Rare each independently C-Calkylidene group or C-Calkenylidene group; Aand Aare each independently aryl, isoaryl, or aryl or isoaryl optionally substituted by halogen, &#x2014;CN, &#x2014;NO, &#x2014;OH, &#x2014;SH, &#x2014;OR, &#x2014;SR, &#x2014;R, &#x2014;R&#x2014;OR, &#x2014;C(O)R, &#x2014;S(O)R, &#x2014;S(O)R, &#x2014;NRR, &#x2014;C(O)OR, &#x2014;C(O)NRR, &#x2014;O(O)CR, &#x2014;S(O)CRor &#x2014;NR(O)CR, wherein Ris C-Calkyl, Rand Rare each independently hydrogen, C-Calkyl, aryl or substituted aryl; and X and Y are each independently oxygen; and the compound of formula (I) does not include phenethyl caffeate. 

Use of phenethyl caffeate derivatives in the preparation of a medicament against tumor angiogenesis

This invention relates to caffeic acid derivatives and improving viability of neuronal cells by contacting neuronal cells by caffeic acid derivatives as shown in the specification.

Caffeic acid derivatives and their use in improving neuronal cell viability

A method for producing caffeic acid phenyl ester and its analogues, which includes the steps of: (i) reacting, in a solvent, a salt of a compound of formula (II) with an organic halide having the formula X&#x2014;R-Ain the presence of an iodide catalyst having the formula M-I to produce caffeic acid phenyl ester or its analogue, wherein A1, R1, Q, Y, X, R2, and M are defined herein; and (ii) isolating the caffeic acid phenyl ester or its analogue from the solvent.

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Beijing, China

Junyi Liu