Genentech, Inc.

F. Hoffmann-la Roche Ag

Junyan Ji

Jun Liu

Yuchang John Wang

Arick Michael Brown

Jacqueline Yvonne Tyler

The disclosure provides pharmaceutical compositions comprising mosunetuzumab and methods of using the same.

Pharmaceutical compositions of mosunetuzumab and methods of use

The invention provides methods of reducing fouling of ultrafiltration membranes in processes wherein virus particles are removed from aqueous solutions comprising virus particles and at least one protein by adding a surfactant or non-surfactant, non-ionic agent to the aqueous solution prior to filtration. The invention also provides methods to dissociate protein aggregates or to reduce the formation of protein aggregates by adding a surfactant or non-surfactant, non-ionic agent to the protein solution.

Protein purification methods

The invention relates to use of non-surfactant compounds including, for example, polyoxyethylene (POE) sorbitans and polyethylene glycols (PEGs), for stabilizing protein-containing formulations and for the prevention of aggregation of proteins in such formulations.

Growing community of inventors

South San Francisco, CA, United States of America

Junyan Ji