Yamanouchi Pharmaceutical Company Ltd.

Junya Ohmori

Shuichi Sakamoto

Takeshi Suzuki

Isao Yanagisawa

Mitsuaki Ohta

Shin-ichi Tsukamoto

Keiji Miyata

Akira Matsuhisa

Masamichi Okada

Tokuo Koide

Masao Sasamata

Kazuyuki Hidaka

Takeshi Murakami

Hirokazu Kubota

Kyoichi Maeno

Takenori Kimura

Jun-ichi Shishikura

Takuma Morita

Kazuhiro Nakato

Imidazole-substituted quinoxalinedione derivatives

Thiophene derivative and pharmaceutical composition thereof

N-(3-pyrrolidinyl) benzamide derivative

A process is provided for preparing a tetrahydrobenzimidazole derivative represented by Formula (Ib): ##STR1## wherein Het representa s heterocyclic group which may be substituted with 1 to 3 substituents selected from the group consisting of a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl-lower alkyl group, an aralkyl group, a lower alkoxycarbonyl group, and a halogen atom; and X.sup.2 represents a single bond connected to the carbon atom of the heterocyclic ring as represented by Het. The process comprises reacting a heterocyclic compound represented by Formula (IIIa):

5-substituted tetrahydrobenzimidazole compounds

A tetrahydrobenzimidazole derivative represented by formula (I): ##STR1## wherein Het represents a heterocyclic group which may be substituted with 1 to 3 substituents selected from the group consisting of a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl-lower alkyl group, an aralkyl group, a lower alkoxy group, a nitro group, a hydroxyl group, a lower alkoxycarbonyl group, and a halogen atom; and X represents a single bond or --NH-- which is bonded to the carbon atom or nitrogen atom of the heterocyclic ring, or a pharmaceutically acceptable salt thereof. The compound of formula (I) and a salt thereof exhibits antagonism against 5-HT.sub.3 receptor.

Tetrahydrobenzimidazole derivatives and pharmaceutical compositions

Fused pyrazine derivatives

Growing community of inventors

Ibaraki, Japan

Junya Ohmori