Astellas Pharma Gmbh

Fujisawa Pharmaceutical Company, Ltd.

Sumitomo Bakelite Company Limited

Meiji Co., Ltd.

Research Institute of Innovative Technology for the Earth

Junya Ishida

Nobukiyo Konishi

Kazuhiko Take

Shinji Shigenaga

Hidenori Azami

Yoshiteru Eikyu

Kazuo Nakai

Hiroshi Miyake

Masayuki Inui

Natsuko Kayakiri

Hidenori Ohki

Takashi Manabe

Tadashi Terasaka

Kazumi Hiraga

Masako Suda

Masataka Morita

Toshio Yamanaka

Hiroaki Mizuno

Takuya Makino

Shigeki Kunikawa

Hiroaki Ohtake

Ayako Toda

Yu Harayama

Kazuji Tamura

Nobutaka Yahiro

Hiroshi Sasaki

Motofumi Takahashi

Masayoshi Hashizume

Provided is a microorganism that is able to produce 2-phenylethanol at a high concentration, and a method of efficiently producing 2-phenylethanol by using a saccharide as a raw material. Provided is a coryneform bacterium transformant in which a shikimate pathway is activated, and further, a gene that encodes an enzyme having phenylpyruvate decarboxylase activity is introduced in such a manner that the gene can be expressed. Also provided is a 2-phenylethanol producing method that includes causing the coryneform bacterium transformant according to the present disclosure to react in water containing a saccharide.

Coryneform bacterium transformant and method for producing 2-phenylethanol using same

The present invention relates to a method for producing a cheese-flavored substance, including adding a bacterial cell disrupted product obtained by disrupting lactic acid bacteria and an enzyme to a milk raw material to cause a reaction. The present invention can provide a method for producing a cheese-flavored substance which can safely and efficiently produce a cheese-flavored substance having a more natural cheese flavor at low-cost with simple operation.

Method for producing cheese-flavored substance

The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, a process for preparation thereof, a pharmaceutical composition comprising the same, and a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.

Cyclic peptide compounds

This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.

Piperazine derivatives

This invention relates to piperazine derivatives of the formula:wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.

Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists

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Tokyo, Japan

Junya Ishida