Emory University

Pharmasset, Inc.

University of Georgia Research Foundation, Inc.

Beth Israel Deaconess Medical Center, Inc.

Cocrystal Pharma, Inc.

Other

Rfs Pharma LLC

Leland Stanford Junior University

Gilead Pharmasset LLC

Junxing Shi

Raymond F Schinazi

Chung K Chu

Yongseok Choi

Dennis C Liotta

Kyeong Lee

Joon H Hong

J Jeffrey McAtee

Michael J Otto

Steven J Coats

Franck Amblard

Kyoichi A Watanabe

Richard Anthony Whitaker

Longhu Zhou

Hongwang Zhang

Tamara Rosario McBrayer

Erik Alan Gustafson

Joyce D Fingeroth

Peiyuan Wang

Jinfa Du

Wojciech Stec

Byoung-Kwon Chun

Robert Todd Striker

Giuseppe Gumina

Youhoon Chong

Byoung Kwon Chun

Wojciech Kolonia Wola Zaradzynski Stec

The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as also pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof as pharmaceutical compositions and methods for treatment or prevention of HCV infection.

Potent and selective inhibitors of hepatitis C virus

2'-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein

2' Fluoronucleosides

A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an effective amount of a 5-substituted uracil nucleoside or its pharmaceutically acceptable salt or prodrug, optionally in a pharmaceutically acceptable diluent or excipient.

Treatment of EBV and KHSV infection and associated abnormal cellular proliferation

2'-fluoronucleosides

The present invention includes compounds and compositions of &#xae;-'-fluoronucleoside phosphonates, as well as methods to treat HIV, HBV, HCV or abnormal cellular proliferation comprising administering said compounds or compositions.

2'-fluoronucleoside phosphonates as antiviral agents

The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-&#x3b2;-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.

Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidines and purines and their derivatives

2-fluoronucleosides

The present invention is directed to a method and composition of treating or preventing viral infections, in particular, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections, in human patients or other animal hosts, comprising the administration of N.sup.4-acyl-2',3&#x2032;-dideoxy-5-fluorocytidine or N.sup.4-acyl-2&#x2032;,3&#x2032;-didehyd-ro-2&#x2032;,3&#x2032;-dideoxy-5-fluorocytidine, and pharmaceutically acceptable salts, prodrugs, and other derivatives thereof.

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The present invention is directed to a compound, method and composition of treating or preventing viral infections, in particular, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections, in human patients or other animal hosts, comprising the administration of N-acylcytosine-1,3-dioxolane and pharmaceutically acceptable salts, prodrugs, and other derivatives thereof.

N4-acylcytosine-1,3-dioxolane nucleosides for treatment of viral infections

A method for the treatment or prevention of Flaviviridae infections, in particular, hepatitis C virus infection, in a host, and in particular, a human, is provided that includes administering an effective amount of a &#x3b2;-L- or &#x3b2;-D-2',3&#x2032;-dideoxynucleoside or a pharmaceutically acceptable salt or prodrug thereof, optionally in a pharmaceutically acceptable diluent or excipient.

A class of 2'-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formula: wherein

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Duluth, GA, United States of America

Junxing Shi