The United States of America, As Represented by the Secretary, Department of Health and Human Services

Junxia Wei

Ira H Pastan

Mitchell Ho

Masanori Onda

Tapan K Bera

Disclosed is a molecule comprising: (a) a first domain, which comprises a targeting moiety; (b) a second domain, which comprises an albumin binding domain (ABD), (c) a third domain, which comprises a furin cleavage sequence ('FCS'), which FCS is cleavable by furin; and (d) a fourth domain, which comprises an optionally substituted Domain III fromexotoxin A (“PE”). Related nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, methods of producing the molecule, methods of treating or preventing cancer in a mammal, and methods of inhibiting the growth of a target cell are also disclosed.

Immunotoxins with albumin binding domain

Disclosed is a molecule comprising: (a) a first domain, which comprises a targeting moiety; (b) a second domain, which comprises an albumin binding domain (ABD), (c) a third domain, which comprises a furin cleavage sequence ('FCS'), which FCS is cleavable by furin; and (d) a fourth domain, which comprises an optionally substituted Domain III fromexotoxin A ('PE'). Related nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, methods of producing the molecule, methods of treating or preventing cancer in a mammal, and methods of inhibiting the growth of a target cell are also disclosed.

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Rockville, MD, United States of America

Junxia Wei