Massachusetts Institute of Technology

The Brigham and Women's Hospital, Inc.

The General Hospital Corporation

Junwei Li

Robert Samuel Langer

Carlo Giovanni Traverso

Malvika Verma

Christoph Winfried Johannes Steiger

Feyisope Eweje

John Ashraf Fou Salama

Nhi Phan

Jacqueline Chu

Hen-Wei Huang

Ameya R Kirtane

Yunhua Shi

Thomas Wang

Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

Gastroretentive articles for alcohol sensing

The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the monomer, dopamine, polymerizes in vivo to form a polymer on a tissue. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.

Tissue catalyzed growth of polymer as epithelial linings for therapy

Growing community of inventors

Cambridge, MA, United States of America

Junwei Li