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Suzhou Yi-hua Biomedical Technology Co., Ltd

Suzhou Ronnsi Pharma Co., Ltd.

Junting Sun

Yi Shan Jiang

Wu Chen

Xiaohua Lu

Xiaoming Li

Xiujuan Ding

Yongbao Li

Yiming Yao

Ningxia Wang

Xi Chong

Qiaoyun Zhou

Jiangen Qian

Hua Zhou

Caijuan Jin

Yongsheng Jin

Yihao Zhu

Provided is a low-molecular-weight holothurian glycosarninoglycan, with the constituent units thereof being a glucuronic acid group, an N-acetaminogalactose group and a fucose group, and a sulfate ester group or acetyl ester group thereof. Glucuronic acid and N-acetaminogalactose are interconnected via &#x3b2;(1-3) and &#x3b2;(1-4) glucosidic bonds to form a backbone of a disaccharide repeating structural unit, and a fucose group is connected to the backbone as a side chain. On a molar ratio basis, the ratio of the glucuronic acid group:the N-acetaminogalactose group:the fucose group is 1:(0.8-1.2):(0.6-1.2). In the structure of the low-molecular-weight holothurian glycosaminoglycan, 10-30% of glucuronic acid groups are modified, on the 2-position, with a sulfate ester group, and the rest are hydroxyl groups; and a proportion of 10-30% of fucose groups is modified, on the 2-position, with an acetyl ester group, and the rest are hydroxyl or sulfate ester groups. The low-molecular-weight holothurian glycosarninoglycan of the present invention has anti-inflammation, anti-vasculopathy, anti-tumor or anti-tumor-metastasis functions, and the effect of improving learning and memory abilities, and can be used for preparing a related drug or health-care product.

Low-molecular-weight holothurian glycosaminoglycan and use thereof

Growing community of inventors

Jiangsu, China

Junting Sun