Canon Kabushiki Kaisha

International Business Machines Corporation

International Display Technology Co., Ltd.

Junta Yamamichi

Hidenori Shiotsuka

Norihiko Utsunomiya

Tetsunori Ojima

Satoru Nishiuma

Satoru Hatakeyama

Takeshi Imamura

Tomohiro Yamada

Tsuyoshi Nomoto

Yoichiro Handa

Miki Ogawa

Masaru Kaieda

Ryo Kuroda

Takashi Ikeda

Hideaki Okamoto

Masaya Ogino

Mie Okano

Yuichi Momoi

Norihhiko Utsunomiya

A substrate of a target substance detection element to be used for a detection apparatus for detecting a target substance, utilizing surface plasmon resonance, comprises a base and a metal structure arranged on the surface of the base in a localized manner or a metal film having an aperture and arranged on the surface of the base, the metal structure or the aperture, whichever appropriate, having at least either of a loop section and a crossing section.

Substrate of target substance detection element to be used in apparatus for detecting target substance by utilizing surface plasmon resonance and detection element and detection apparatus using same

A detection device and a detecting method using the detection device are provided in which a magnetic particle is used as a marker particle, and the ratio of a region with reversed magnetization to the whole area of a free layer of a magnetoresistive effect film is increased by a stray magnetic field generated through a biochemical reaction from the magnetic particle remaining on a surface of the magnetoresistive effect film, so that a large detection signal is obtained and obtained detection data can be stored with stability.

Detecting method, detection device and detection kit

The present invention enables to classify and measure two or more kinds of target substances which have the same recognition site recognized by a specific capturing body. Specifically, by using a target substance detecting element for detecting two or more targets, whose kinds are different mutually, at the same time, the target substance detecting element, characterized by having a base material, two or more kinds of metal structures provided on a surface of the base material, and a target capturing body provided on each surface of the two or more kinds of metal structures, and in that the number of kinds of the metal structures are equal to or more than the number of kinds of the target substances, concentrations of the two or more kinds of target substances can be calculated by integrating and analyzing detection signals detected from the target substance detecting element.

Target substance detecting element, target substance detecting apparatus, and target substance detecting method

A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.

Recognition chip for target substance, and detection method and device for the same

A target substance detecting device, which is a device that has a substrate, a structure disposed on a substrate surface in isolation using a metal, and a target substance trapping substance disposed on the structure, and which is for detecting a target substance using localized plasmon resonance, characterized in that the above-mentioned structure is constructed by stacking at least two metal layers, sandwiching a non-conductive layer between the metal layers.

Target substance detecting device, target substance detecting method using the same, and detecting apparatus and kit therefor

A capturing molecule having an association containing a plurality of polypeptide chains that specifically bind to different sites of a target substance, characterized in that each of the polypeptide chains has a domain having a hypervariable loop structure at a binding site binding to the target substance and an association portion for forming the association, and the polypeptide chains are associated via the association portions present in the polypeptide chains.

Bispecific capturing molecule

A substrate for forming a target substance detecting device includes a supporting member, an underlying layer disposed on a surface of the supporting member, and a metal pattern layer, disposed on a surface of the underlying layer, for being bound to a target substance trapping substance capable of trapping a target substance in a specimen solution at least containing water as a liquid medium to detect the target substance by utilizing plasmon resonance. The underlying layer has a refractive index nb satisfying the following relationship:0.90 na&#x2266;nb&#x2266;1.05 na,wherein na represents a refractive index of water.

Substrate for target substance detecting device, target substance detecting device, target substance detecting apparatus and method using the same, and kit therefor

A capturing molecule having not less than two domains specifically binding to different sites of a target substance, wherein the not less than two domains comprise (1) a first domain having a hypervariable loop structure at a binding site to the target substance, and (2) a second domain having no hypervariable loop structure at a binding site to the target substance.

Target substance capturing molecule

A detection method for detecting a plurality of different substances contained in a specimen using a label, includes sequentially the steps of flowing the specimen through a detecting element having a first substance trapping portion immobilizing a first substance trapping body, a second substance trapping portion immobilizing a second substance trapping body, and a channel, and flowing a solution containing the label through the first substance trapping portion immobilizing the first substance trapping body and the second substance trapping portion immobilizing the second substance trapping body. Additional steps include flowing a solution for generating a signal from the label through the first substance trapping portion immobilizing the label to thereby acquire a signal from, and flowing a solution for generating a signal from the label through the second substance trapping portion immobilizing the label to thereby acquire a signal.

Detecting element and detection method

A target substance detection method for detecting a target substance in a specimen, comprises the steps of contacting with a specimen a target substance detecting element comprised of a base, a metal structure and a first capturing body for capturing a target substance; contacting with the target substance detecting element a labeling material comprised of a labeling substance and a second capturing body for capturing a target substance; and acquiring an absorption spectrum (A) of the target substance detecting element contacted with the specimen and the labeling material, wherein the employed labeling substance is a substance that a slope of a tangent of an absorption spectrum (C) of the labeling substance at a peak wavelength (&#x3bb;) of an absorption spectrum (B) of the target substance detecting element is larger than zero.

Target substance detection method and target substance detection kit

An apparatus and method for capturing a target substance in a sample. The method includes the steps of preparing particles capable of capturing the target substance in a dispersed state in a fluid, aggregating the particles, and allowing the particles to capture the target substance in the sample by bringing the sample into contact with the particles aggregated.

Apparatus for capturing target substance

A device for introducing fine magnetic particles into a cell by applying an electric field to a reaction field where a sample solution containing cells and the fine magnetic particles are introduced, in order to form pores in the surface of the cell, and then applying a magnetic field to the reaction field to introduce the fine magnetic particles into the cell through the pore(s).

Device and method for introducing particle into cell and device and method for collecting particle from cell

A method for capturing a target substance in a sample, comprising the steps of preparing particles capable of capturing the target substance in a dispersed state in a fluid, aggregating the particles, and allowing the particles to capture the target substance in the sample by bringing the sample into contact with the particles aggregated.

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Yokohama, Japan

Junta Yamamichi